Chapter title |
Low-dose combination therapy of DUP-785 and RS-61443 prolongs cardiac allograft survival in rats.
|
---|---|
Chapter number | 141 |
Book title |
Transplant International Official Journal of the European Society for Organ Transplantation
|
Published in |
Transplant International, January 1992
|
DOI | 10.1007/978-3-642-77423-2_141 |
Pubmed ID | |
Book ISBNs |
978-3-54-055342-7, 978-3-64-277423-2
|
Authors |
W O Bechstein, Y Suzuki, T Kawamura, B Jaffee, A Allison, D A Hullett, H W Sollinger, Bechstein, W. O., Suzuki, Y., Kawamura, T., Jaffee, B., Allison, A., Hullett, D. A., Sollinger, H. W. |
Abstract |
The introduction of cyclosporine into the immunosuppressive armamentarium has revolutionized transplant surgery with significant improvements in graft survival. The apparent lack of effect of cyclosporine on humoral rejection mechanisms makes the search for other immunosuppressive agents desirable. Two anti-metabolites affecting nucleotide synthesis via different pathways have recently been evaluated for their immunosuppressive potential. DUP-785 (DUP), also known as brequinar sodium, reversibly inhibits de novo pyrimidine synthesis by blocking dihydro-orotate dehydrogenase, thus resulting in the deletion of critical precursors for RNA and DNA synthesis. RS-61443, a morpholinoethyl ester of mycophenolic acid, reversibly and non-competitively blocks inosin monophosphate dehydrogenase, the key enzyme in purine de novo synthesis. A possible additive effect of both drugs was investigated in the rat heart allograft model. |
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Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2017.
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#7,455,523
of 22,792,160 outputs
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#712
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#12,494
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Outputs of similar age from Transplant International
#2
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