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Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

Overview of attention for book
Attention for Chapter 4: Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
2 news outlets
twitter
11 tweeters
facebook
8 Facebook pages
video
1 video uploader

Citations

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8 Dimensions

Readers on

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46 Mendeley
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Chapter title
Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities.
Chapter number 4
Book title
Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases
Published in
Fortschritte der Arzneimittelforschung Progress in drug research Progrès des recherches pharmaceutiques, January 2015
DOI 10.1007/978-3-0348-0927-6_4
Pubmed ID
Book ISBNs
978-3-03-480926-9, 978-3-03-480927-6
Authors

Powanda, Michael C, Whitehouse, Michael W, Rainsford, K D, Michael C. Powanda, Michael W. Whitehouse, K D. Rainsford, Powanda, Michael C., Whitehouse, Michael W., Rainsford, K D.

Abstract

Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 20%
Student > Master 7 15%
Researcher 6 13%
Professor > Associate Professor 2 4%
Professor 1 2%
Other 3 7%
Unknown 18 39%
Readers by discipline Count As %
Medicine and Dentistry 4 9%
Biochemistry, Genetics and Molecular Biology 4 9%
Nursing and Health Professions 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Engineering 2 4%
Other 7 15%
Unknown 22 48%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2022.
All research outputs
#1,222,865
of 22,100,013 outputs
Outputs from Fortschritte der Arzneimittelforschung Progress in drug research Progrès des recherches pharmaceutiques
#2
of 32 outputs
Outputs of similar age
#25,422
of 405,926 outputs
Outputs of similar age from Fortschritte der Arzneimittelforschung Progress in drug research Progrès des recherches pharmaceutiques
#1
of 3 outputs
Altmetric has tracked 22,100,013 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one scored the same or higher as 30 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them