Chapter title |
Spherical Topic Models for Imaging Phenotype Discovery in Genetic Studies.
|
---|---|
Chapter number | 10 |
Book title |
Bayesian and grAphical Models for Biomedical Imaging
|
Published in |
Forest Ecosystems, January 2014
|
DOI | 10.1007/978-3-319-12289-2_10 |
Pubmed ID | |
Book ISBNs |
978-3-31-912288-5, 978-3-31-912289-2
|
Authors |
Kayhan N Batmanghelich, Michael Cho, Raul San Jose, Polina Golland, Kayhan N. Batmanghelich, Batmanghelich, Kayhan N., Cho, Michael, Jose, Raul San, Golland, Polina |
Abstract |
In this paper, we use Spherical Topic Models to discover the latent structure of lung disease. This method can be widely employed when a measurement for each subject is provided as a normalized histogram of relevant features. In this paper, the resulting descriptors are used as phenotypes to identify genetic markers associated with the Chronic Obstructive Pulmonary Disease (COPD). Features extracted from images capture the heterogeneity of the disease and therefore promise to improve detection of relevant genetic variants in Genome Wide Association Studies (GWAS). Our generative model is based on normalized histograms of image intensity of each subject and it can be readily extended to other forms of features as long as they are provided as normalized histograms. The resulting algorithm represents the intensity distribution as a combination of meaningful latent factors and mixing co-efficients that can be used for genetic association analysis. This approach is motivated by a clinical hypothesis that COPD symptoms are caused by multiple coexisting disease processes. Our experiments show that the new features enhance the previously detected signal on chromosome 15 with respect to standard respiratory and imaging measurements. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 24% |
Researcher | 3 | 18% |
Professor > Associate Professor | 3 | 18% |
Student > Bachelor | 2 | 12% |
Student > Doctoral Student | 2 | 12% |
Other | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 7 | 41% |
Medicine and Dentistry | 3 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Engineering | 2 | 12% |
Arts and Humanities | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 12% |