Chapter 1 Methods for Quantifying Insulin Sensitivity and Determining Insulin Time-Action Profiles

Chapter 2 Assessment of β-Cell Function

Chapter 3 Isotopic Tracers for the Measurement of Metabolic Flux Rates

Chapter 4 Imaging Techniques for the Assessment of Ectopic Fat in Liver and Skeletal Muscle

Chapter 5 Positron-Emission Tomography and Computed Tomography Measurement of Brown Fat Thermal Activation: Key Tools for Developing Novel Pharmacotherapeutics for Obesity and Diabetes

Chapter 7 Measurement of Energy Expenditure

Chapter 8 Omics: Potential Role in Early-Phase Drug Development

Chapter 9 Early Phase Metabolic Research with Reference to Special Populations

Chapter 10 Quantitative Approaches in Translational Research: An Overview

Chapter 11 Computational Modelling of Energy Metabolism and Body Composition Dynamics

Chapter 12 Regulatory Considerations for Early Clinical Development of Drugs for Diabetes, Obesity, and Cardiometabolic Disorders