| Chapter title |
Inflammation of the brain after ischemia.
|
|---|---|
| Chapter number | 7 |
| Book title |
Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma
|
| Published in |
Acta neurochirurgica Supplement, January 1996
|
| DOI | 10.1007/978-3-7091-9465-2_7 |
| Pubmed ID | |
| Book ISBNs |
978-3-70-919467-6, 978-3-70-919465-2
|
| Authors |
Kyuya Kogure, Y. Yamasaki, Y. Matsuo, H. Kato, H. Onodera, Kogure, Kyuya, Yamasaki, Y., Matsuo, Y., Kato, H., Onodera, H. |
| Abstract |
Cytokines which promote emigration of leukocytes from the vascular lumen into the injured brain tissue are produced at the site of incipient cerebral infarction. The blood-borne invaders then accelerate the decomposition of brain cells by their toxic by-products, phagocytic action, and by the immune reaction. Recently accumulated data in our laboratories and other research facilities show that depleting the amount of circulating leukocytes or administering anti-inflammatory chemicals such as cytokine blocking agents, anti-adhesion molecule antibodies, and immunosuppressants effectively minimize the size of ischemia induced cerebral infarction. Based on the fact the leukocyte invasion of the affected brain tissue occurs 6 to 24 hours after onset of ischemia, administration of an anti-inflammatory therapy may widen the therapeutic window against stroke. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 50% |
| Professor | 1 | 17% |
| Student > Doctoral Student | 1 | 17% |
| Unknown | 1 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 33% |
| Medicine and Dentistry | 2 | 33% |
| Neuroscience | 1 | 17% |
| Unknown | 1 | 17% |