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Mechanisms of DNA Damage and Repair

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Table of Contents

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    Book Overview
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    Chapter 1 Introduction to Mechanisms of DNA Damage and Repair
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    Chapter 2 History of Radiation Biology from a Personal Point of View
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    Chapter 3 Comparison of Mechanisms for DNA Strand Break Formation by the Direct and Indirect effect of Radiation
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    Chapter 4 Electron Spin Resonance Studies of the Mechanism of Radiation Damage to DNA
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    Chapter 5 Free Radical Mechanisms of DNA Base Damage
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    Chapter 6 Peroxyl Radicals of Nucleic Acids and their Components
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    Chapter 7 Radiation-Induced Peroxidation of DNA and Effects of Redox-Active Agents
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    Chapter 8 The Radiation Chemistry of the Purine Bases within DNA and Related Model Compounds
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    Chapter 9 Bacteriophage DNA as a Model for Correlation of Radical Damage to DNA and Biological Effects
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    Chapter 10 Ultrafast Chemical Repair of DNA Single and Double Strand Break Precursors in Irradiated V79 Cells
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    Chapter 11 Assessment of DNA Damage by Filter Elution Assays
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    Chapter 12 DNA Modification by Sulfur Mustards and Nitrosoureas and Repair of these Lesions
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    Chapter 13 Intragenomic Localization of Carcinogen-DNA Damage
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    Chapter 14 Ionizing Radiation Induced DNA Damage: Identities and DNA Repair
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    Chapter 15 Effects of LET ∞ on the Fate of DNA Damage Induced in Rabbit Sensory Cells In Situ : Fundamental Aspects
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    Chapter 16 Radiation Damage to DNA in Various Animal Tissues: A Comparison of Yields and Repair In Vivo and In Vitro
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    Chapter 17 Differential Regulation of Base and Nucleotide Excision Repair in Mammalian Cells
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    Chapter 18 Immediate and Repair Induced DNA Double Strand Breaks in Mammalian Cells
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    Chapter 19 DNA-Protein Cross-Links: New Insights into their Formation and Repair in Irradiated Mammalian Cells
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    Chapter 20 DNA-to-Protein Crosslinks and Backbone Breaks caused by Far- and Near-Ultraviolet, and Visible Light Radiations in Mammalian Cells
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    Chapter 21 Sequence Specificity and Biological Consequences of Drugs that Bind Covalently in the Minor Groove of DNA
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    Chapter 22 Molecular Recognition of DNA Binding Agents: High-Field 1 H and 3 1 P One- and Two-Dimensional NMR Studies on the 1:1 Intercalation Complexes of Mitoxantrone with Selected Oligodeoxyribonucleotides
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    Chapter 23 DNA Binding and Biological Properties of Bis and Tris Interacting Molecules
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    Chapter 24 Novel Types of DNA-Sugar Damage in Neocarzinostatin Cytotoxicity and Mutagenesis
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    Chapter 25 DNA-Drug Binding and Control of Genetic Information
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    Chapter 26 Computer-Aided Design of New DNA Intercalators
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    Chapter 27 Differential Expression of SOS Genes in an E. Coli Mutant Producing Unstable LexA Protein Enhances Excision Repair But Inhibits Mutagenesis
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    Chapter 28 Mutagenic DNA repair in bacteria: the role of UmuDC and MucAB.
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    Chapter 29 The Repair of Pyrimidine Dimers Via a DNA-Glycosylase Mechanism
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    Chapter 30 The Involvement of an E. Coli Multiprotein Complex in the Complete Repair of UV-Damaged DNA
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    Chapter 31 Pyrimidine Dimers Induced Alteration of DNA Tertiary Structure Evidence for Unwinding and Shortening
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    Chapter 32 Mismatch correction.
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    Chapter 33 Molecular approaches to the study of nucleotide excision repair in eukaryotes.
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    Chapter 34 Restoration of DNA Repair in UV-Sensitive Chinese Hamster Ovary Cell by the denV Gene from Bacteriophage T4
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    Chapter 35 The Adaptive Response of Mammalian Cells to Alkylating Agents
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    Chapter 36 DNA Glycosylases in DNA Repair
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    Chapter 37 Apurinic sites as common intermediates in mutagenesis.
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    Chapter 38 The Repair of Uracil-Containing DNA
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    Chapter 39 Metabolic consequences of DNA damage: the role of poly (ADP-ribose) polymerase as mediator of the suicide response.
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    Chapter 40 DNA Damage, DNA Repair and Induced Mutagenesis: Some Enzymological and Structural Considerations
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    Chapter 41 Mechanisms of mutagenesis of E. coli by ultraviolet light.
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    Chapter 42 Activation of H-ras-1 oncogenes by chemical carcinogens.
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    Chapter 43 Activation of the c- myc Oncogene
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    Chapter 44 Salmonella Tester Strains: Mutational Targets and Correlation with Animal Carcinogenicity and Teratogenicity
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    Chapter 45 Mechanisms of Spontaneous Mutagenesis: Clues from Mutational Specificity
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    Chapter 46 Use of Gradient Denaturing Gels to Determine Mutational Spectrum in Human Cells
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    Chapter 47 Urinary N-Nitrosamino Acids as Indices of Endogenous Formation of N-Nitroso Compounds
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    Chapter 48 Application of Monoclonal Antibodies to Monitor Human Exposure to Aflatoxin B1
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    Chapter 49 Blood Proteins as Carcinogen Dosimeters
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    Chapter 50 Development of an Avidin-Biotin Amplified Enzyme-Linked Immunoassay for Detection of DNA Adducts of the Human Bladder Carcinogen 4-Aminobiphenyl
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    Chapter 51 Intragenomic Heterogeneity in DNA Damage Processing: Potential Implications for Risk Assessment
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    Chapter 52 The Role of Pharmacokinetics in Risk Assessment
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    Chapter 53 Immunologic quantification of carcinogen-DNA adducts.
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    Chapter 54 Interpretation of Genotoxicity Data in Assessing the Risks of Genetic Diseases
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    Chapter 55 Background Levels of DNA Damage in the Population
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    Chapter 56 Use of Models in Low-Dose Extrapolation
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    Chapter 57 Problems in Interspecies Comparisons
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    Chapter 58 The Time to Tumor Approach in Risk Assessment
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    Chapter 59 The Role of Nutritional Factors in Cellular Protection Against DNA Damage, Altered Gene Expression and Malignant Transformation
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    Chapter 60 The Role of Risk Assessment in Food Safety Policy
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Title
Mechanisms of DNA Damage and Repair
Published by
Springer US, November 2013
DOI 10.1007/978-1-4615-9462-8
ISBNs
978-1-4615-9464-2, 978-1-4615-9462-8
Editors

Simic, Michael G., Grossman, Lawrence, Upton, Arthur C., Bergtold, David S.

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The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 25%
Researcher 1 25%
Student > Master 1 25%
Unknown 1 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 50%
Computer Science 1 25%
Unknown 1 25%