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RNA and Cancer

Overview of attention for book
Cover of 'RNA and Cancer'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 RNA and Cancer
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    Chapter 2 RNA and Cancer
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    Chapter 3 RNA and Cancer
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    Chapter 4 Alternative Splicing of Tumor Suppressors and Oncogenes
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    Chapter 5 RNA and Cancer
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    Chapter 6 The Perinucleolar Compartment: RNA Metabolism and Cancer
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    Chapter 7 Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer
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    Chapter 8 RNA and Cancer
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    Chapter 9 Oligonucleotide Therapeutics in Cancer
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    Chapter 10 Clinical Perspective on Chemo-Resistance and the Role of RNA Processing
Attention for Chapter 9: Oligonucleotide Therapeutics in Cancer
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

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3 X users

Citations

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3 Dimensions

Readers on

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12 Mendeley
Summary X Dimensions citations
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Chapter title
Oligonucleotide Therapeutics in Cancer
Chapter number 9
Book title
RNA and Cancer
Published in
Cancer treatment and research, February 2016
DOI 10.1007/978-3-642-31659-3_9
Pubmed ID
24222360
Book ISBNs
978-3-64-231658-6, 978-3-64-231659-3
Authors

Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani, Ryszard Kole, Wan J, Bauman JA, Graziewicz MA, Sazani P, Kole R, Wan, Jing, Bauman, John A., Graziewicz, Maria Anna, Sazani, Peter, Kole, Ryszard

Abstract

Alterations in pre-mRNA splicing can have profound effects on gene expression and lead to cellular transformation. Oligonucleotide therapeutics are drugs that manipulate gene expression and improve the disease state. Antisense oligonucleotides hybridize with a target mRNA to downregulate gene expression via an RNase H-dependent mechanism. Additionally, RNase H-independent splice switching oligonucleotides (SSO) modulate alternative or aberrant splicing, to favor the therapeutically relevant splicing product. This chapter summarizes the progress made in the application of these oligonucleotide drugs in the treatment of cancer.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 17%
Student > Postgraduate 2 17%
Student > Doctoral Student 1 8%
Student > Bachelor 1 8%
Student > Master 1 8%
Other 3 25%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Biochemistry, Genetics and Molecular Biology 2 17%
Agricultural and Biological Sciences 2 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Chemistry 1 8%
Other 0 0%
Unknown 2 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2013.
All research outputs
#13,699,566
of 22,731,677 outputs
Outputs from Cancer treatment and research
#79
of 164 outputs
Outputs of similar age
#197,343
of 396,679 outputs
Outputs of similar age from Cancer treatment and research
#8
of 21 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 164 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,679 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.

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