Chapter title |
Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation
|
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Chapter number | 4 |
Book title |
Ultraviolet Light in Human Health, Diseases and Environment
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-56017-5_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-956016-8, 978-3-31-956017-5
|
Authors |
Phillip R. Musich, Zhengke Li, Yue Zou, Musich, Phillip R., Li, Zhengke, Zou, Yue |
Abstract |
The sensitivity of Xeroderma pigmentosa (XP) patients to sunlight has spurred the discovery and genetic and biochemical analysis of the eight XP gene products (XPA-XPG plus XPV) responsible for this disorder. These studies also have served to elucidate the nucleotide excision repair (NER) process, especially the critical role played by the XPA protein. More recent studies have shown that NER also involves numerous other proteins normally employed in DNA metabolism and cell cycle regulation. Central among these is ataxia telangiectasia and Rad3-related (ATR), a protein kinase involved in intracellular signaling in response to DNA damage, especially DNA damage-induced replicative stresses. This review summarizes recent findings on the interplay between ATR as a DNA damage signaling kinase and as a novel ligand for intrinsic cell death proteins to delay damage-induced apoptosis, and on ATR's regulation of XPA and the NER process for repair of UV-induced DNA adducts. ATR's regulatory role in the cytosolic-to-nuclear translocation of XPA will be discussed. In addition, recent findings elucidating a non-NER role for XPA in DNA metabolism and genome stabilization at ds-ssDNA junctions, as exemplified in prematurely aging progeroid cells, also will be reviewed. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 26% |
Student > Master | 3 | 11% |
Student > Bachelor | 3 | 11% |
Lecturer | 2 | 7% |
Researcher | 2 | 7% |
Other | 1 | 4% |
Unknown | 9 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 30% |
Medicine and Dentistry | 5 | 19% |
Immunology and Microbiology | 1 | 4% |
Computer Science | 1 | 4% |
Physics and Astronomy | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 37% |