Chapter title |
Current management of peripheral T-cell lymphomas.
|
---|---|
Chapter number | 12 |
Book title |
Non-Hodgkin Lymphoma
|
Published in |
Cancer treatment and research, January 2015
|
DOI | 10.1007/978-3-319-13150-4_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-913149-8, 978-3-31-913150-4
|
Authors |
M Gooptu, R Rhoades, B Pro, M. Gooptu, R. Rhoades, B. Pro, Gooptu, M., Rhoades, R., Pro, B. |
Abstract |
Peripheral T-cell lymphomas (PTCLs) are an uncommon group of lymphoproliferative disorders accounting for approximately 10-15 % of all non-Hodgkin lymphomas (NHL) in Western countries. Although PTCLs are associated with poor prognosis, outcomes vary with disease subtype. The standard of care has been anthracycline-based induction combination chemotherapy, however, with the exception of low-risk ALK-positive anaplastic large cell lymphoma, relapse rates are high. Therefore, consolidation with autologous stem cell transplantation is usually recommended for patients deemed candidates, and with aggressive subtypes. In recent years, a number of novel agents including pralatrexate, histone deacetylase inhibitors, immunotoxins, proteasome inhibitors, aurora kinase inhibitors and the CD30 antibody-drug conjugate brentuximab vedotin, have shown promise in the treatment of PTCLs. Studies are underway to explore the activity of these newer agents used in the frontline setting. |
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