Chapter title |
Profiling epigenetic alterations in disease.
|
---|---|
Chapter number | 12 |
Book title |
Epigenetic Contributions in Autoimmune Disease
|
Published in |
Advances in experimental medicine and biology, January 2011
|
DOI | 10.1007/978-1-4419-8216-2_12 |
Pubmed ID | |
Book ISBNs |
978-1-4419-8215-5, 978-1-4419-8216-2
|
Authors |
José Ignacio Martín-Subero, Manel Esteller, Martín-Subero, José Ignacio, Esteller, Manel |
Abstract |
Nowadays, epigenetics is one of the fastest growing research areas in biomedicine. Studies have demonstrated that changes in the epigenome are not only common in cancer, but are also involved in the pathogenesis of noncancerous diseases like immunological, cardiovascular, developmental and neurological/psychiatric disorders. At the same time, during the last years, a technological revolution has taken place in the field of epigenomics, which is defined as the study of epigenetic changes throughout the whole genome. Microarray technologies and more recently, the development of next generation sequencing devices are now providing researchers with tools to draw high-resolution maps of DNA methylation and histone modifications in normal tissues and diseases. This chapter will review the currently available high-throughput techniques for studying the epigenome and their applications for characterizing human diseases. |
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Geographical breakdown
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United States | 1 | 3% |
Sweden | 1 | 3% |
Unknown | 30 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Researcher | 8 | 24% |
Student > Master | 5 | 15% |
Student > Postgraduate | 3 | 9% |
Professor > Associate Professor | 3 | 9% |
Other | 5 | 15% |
Unknown | 2 | 6% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Chemistry | 2 | 6% |
Other | 4 | 12% |
Unknown | 2 | 6% |