Chapter title |
Multiple forms of the Menkes Cu-ATPase.
|
---|---|
Chapter number | 4 |
Book title |
Copper Transport and Its Disorders
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4859-1_4 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7204-2, 978-1-4615-4859-1
|
Authors |
E D Harris, M C Reddy, Y Qian, E Tiffany-Castiglioni, S Majumdar, J Nelson, Harris, Edward D., Reddy, Manchi C. M., Qian, Yongchang, Tiffany-Castiglioni, Evelyn, Majumdar, Sudeep, Nelson, John |
Abstract |
The 5' region of MNK cDNAs has a 45 bp insert terminating at the 5'end with an AGATG sequence. The ATG in the sequence is in-frame with the ATG downstream identified by Vulpe et al (1993) as a translation start site for MNK mRNA. Inserts of 192 bp and 45 bp have been found in the 5' region of MNK mRNAs from BeWo cells, Caco-2 cells and normal human fibroblasts. Extensions to the 5' end of these mRNAs could foretell a modified N-termini in certain forms of the Menkes Cu-ATPase. These modified H2N-terminal extensions are postulated to be targeting signals for post-translational processing and cellular localization. In this report, we provide evidence that the primary Menkes transcript in non-Menkes cells undergoes post-transcriptional splicing that gives rise to multiple transcripts. The data suggest that the Menkes gene is a copper locus that codes for more than one form of the Menkes Cu-ATPase and one of these forms could be a small Cu transport protein. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 1 | 25% |
Student > Ph. D. Student | 1 | 25% |
Student > Postgraduate | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 2 | 50% |
Unknown | 2 | 50% |