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Bacterial Adhesion

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Cover of 'Bacterial Adhesion'

Table of Contents

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    Book Overview
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    Chapter 1 Adhesins of Human Pathogens from the Genus Yersinia
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    Chapter 2 Adhesive Mechanisms of Salmonella enterica
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    Chapter 3 Adhesion Mechanisms of Borrelia burgdorferi
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    Chapter 4 Adhesins of Bartonella spp.
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    Chapter 5 Adhesion Mechanisms of Plant-Pathogenic Xanthomonadaceae
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    Chapter 6 Adhesion by Pathogenic Corynebacteria
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    Chapter 7 Adhesion Mechanisms of Staphylococci
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    Chapter 8 Protein Folding in Bacterial Adhesion: Secretion and Folding of Classical Monomeric Autotransporters
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    Chapter 9 Structure and biology of trimeric autotransporter adhesins.
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    Chapter 10 Crystallography and Electron Microscopy of Chaperone/Usher Pilus Systems
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    Chapter 11 Crystallography of Gram-Positive Bacterial Adhesins
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    Chapter 12 The Nonideal Coiled Coil of M Protein and Its Multifarious Functions in Pathogenesis
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    Chapter 13 Bacterial extracellular polysaccharides.
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    Chapter 14 Carbohydrate Mediated Bacterial Adhesion
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    Chapter 15 The Application of NMR Techniques to Bacterial Adhesins
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    Chapter 16 Electron Microscopy Techniques to Study Bacterial Adhesion
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    Chapter 17 EM Reconstruction of Adhesins: Future Prospects
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    Chapter 18 Atomic Force Microscopy to Study Intermolecular Forces and Bonds Associated with Bacteria
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    Chapter 19 Assessing Bacterial Adhesion on an Individual Adhesin and Single Pili Level Using Optical Tweezers
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    Chapter 20 Short Time-Scale Bacterial Adhesion Dynamics
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    Chapter 21 Deciphering Biofilm Structure and Reactivity by Multiscale Time-Resolved Fluorescence Analysis
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    Chapter 22 Inhibition of Bacterial Adhesion on Medical Devices
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    Chapter 23 Erratum
Attention for Chapter 11: Crystallography of Gram-Positive Bacterial Adhesins
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Chapter title
Crystallography of Gram-Positive Bacterial Adhesins
Chapter number 11
Book title
Bacterial Adhesion
Published in
Advances in experimental medicine and biology, January 2011
DOI 10.1007/978-94-007-0940-9_11
Pubmed ID
Book ISBNs
978-9-40-070939-3, 978-9-40-070940-9
Authors

Vengadesan Krishnan, Sthanam V.L. Narayana

Abstract

Both Gram-negative and Gram-positive pathogens display a multitude of proteins and protein assemblies (pili or fimbriae) on their cell surfaces, which are often used for adherence and initiate colonization and pathogenesis. Adhesive proteins known as MSCRAMMs (microbial surface components recognizing adhesive matrix molecules), anchored by a specific enzyme called sortase in Gram-positive bacteria, target the host's extracellular matrix proteins (ECM) like collagen, fibrinogen and fibronectin. In the past decade, structural analysis by X-ray crystallography has enhanced our understanding of the interactions between MSCRAMMs and the host ECM by revealing several novel structural features that dictate surface protein assembly and the mode of their adhesion to host tissue. The latest focus is on the recently discovered Gram-positive bacterial pili, assembly of which is assisted by yet another specific sortase. Novel features like inter- and intra-molecular isopeptide bonds that facilitate the stability of the pilins, and intra-molecular donor strand complementation to stabilize the adhesin-target interactions are specific to Gram-positive bacteria. This chapter describes and discusses the common structural details between surface proteins and pilins of Gram-positive bacteria and biological implications emanating from these structures.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
France 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 33%
Researcher 5 17%
Student > Doctoral Student 3 10%
Student > Bachelor 3 10%
Professor > Associate Professor 3 10%
Other 4 13%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 50%
Chemistry 5 17%
Biochemistry, Genetics and Molecular Biology 4 13%
Earth and Planetary Sciences 1 3%
Unknown 5 17%