Chapter title |
Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease
|
---|---|
Chapter number | 17 |
Book title |
Cellular Peptidases in Immune Functions and Diseases 2
|
Published in |
Advances in experimental medicine and biology, January 2000
|
DOI | 10.1007/0-306-46826-3_17 |
Pubmed ID | |
Book ISBNs |
978-0-306-46383-9, 978-0-306-46826-1
|
Authors |
Dirk Reinhold, Bernhard Hemmer, Bruno Gran, Andreas Steinbrecher, Stefan Brocke, Thilo Kähne, Sabine Wrenger, Ilona Born, Jürgen Faust, Klaus Neubert, Roland Martin, Siegfried Ansorge |
Abstract |
The ectoenzyme dipeptidyl peptidase IV (DP IV; EC 3.4.14.5; CD26) has been shown to play a crucial role in T cell activation. In the present study, we show by flow cytometry and by enzymatic DP IV assay that myelin basic protein (MBP)-specific, CD4+ T cell clones (TCC) derived from patients with multiple sclerosis (MS) express high levels of DP IV/CD26. The enzymatic activity of resting TCC was found to be three to fourfold higher than on resting peripheral blood T cells and close to that of T cells 48 hours after PHA stimulation. The DP IV inhibitors Lys[Z(NO2)]-thiazolidide and Lys[Z(NO2)]-pyrrolidide suppress in a dose-dependent manner DNA synthesis and IFN-gamma, IL-4, and TNF-alpha production of the antigen-stimulated TCC. These data suggest that CD26 plays a role in regulating activation of autoreactive TCC. Further in vivo investigations will clarify, whether the inhibition of the enzymatic activity of DP IV could be a useful tool for therapeutic interventions in MS and/or other autoimmune diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 5 | 31% |
Other | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Researcher | 2 | 13% |
Student > Ph. D. Student | 1 | 6% |
Other | 3 | 19% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Neuroscience | 2 | 13% |
Psychology | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 2 | 13% |
Unknown | 5 | 31% |