| Chapter title |
Noncoding RNA for Cancer Gene Therapy
|
|---|---|
| Chapter number | 4 |
| Book title |
Current Strategies in Cancer Gene Therapy
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2016
|
| DOI | 10.1007/978-3-319-42934-2_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-942932-8, 978-3-31-942934-2
|
| Authors |
Xiaomin Zhong, Dongmei Zhang, Minmin Xiong, Lin Zhang, Zhong, Xiaomin, Zhang, Dongmei, Xiong, Minmin, Zhang, Lin |
| Abstract |
Gene therapy is a prospective strategy to modulate gene expression level in specific cells to treat human inherited diseases, cancers, and acquired disorders. A subset of noncoding RNAs, microRNAs (miRNAs) and small interference RNAs (siRNAs), compose an important class of widely used effectors for gene therapy, especially in cancer treatment. Functioning through the RNA interference (RNAi) mechanism, miRNA and siRNA show potent ability in silencing oncogenic factors for cancer gene therapy. For a better understanding of this field, we reviewed the mechanism and biological function, the principles of design and synthesis, and the delivery strategies of noncoding RNAs with clinical potentials in cancer gene therapy. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 16% |
| Other | 3 | 12% |
| Student > Bachelor | 2 | 8% |
| Student > Doctoral Student | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 4 | 16% |
| Unknown | 10 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 20% |
| Medicine and Dentistry | 4 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Unspecified | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 12 | 48% |