Chapter title |
Structural proteins of avian infectious bronchitis virus: role in immunity and protection.
|
---|---|
Chapter number | 71 |
Book title |
Coronaviruses
|
Published in |
Advances in experimental medicine and biology, January 1993
|
DOI | 10.1007/978-1-4615-2996-5_71 |
Pubmed ID | |
Book ISBNs |
978-1-4613-6305-7, 978-1-4615-2996-5
|
Authors |
Ignjatovic, J, Galli, L, Jagoda Ignjatovic, Lisa Galli, Ignjatovic, Jagoda, Galli, Lisa |
Abstract |
The antigenicity of the S1, M and N proteins of avian infectious bronchitis virus was compared following immunization of chickens with live and inactivated virus. The N protein was immunodominant antigen inducing cross-reactive antibodies in high titres whereas the S1 glycoprotein induced serotype-specific and cross-reactive antibodies. The M glycoprotein elicited antibodies in low titres and of limited cross-reactivity. Immunization of chickens with the purified N and M proteins did not induce protection against virulent challenge whereas immunization with the S1 glycoprotein prevented replication of nephropathogenic IBV in kidneys but not in tracheas of immunized chickens. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 38% |
Researcher | 3 | 14% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Lecturer | 1 | 5% |
Other | 3 | 14% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 8 | 38% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 3 | 14% |
Unknown | 6 | 29% |