Chapter title |
Tissue hydration in kidneys during preservation: a relaxometric analysis of time-dependent differences between cortex and medulla.
|
---|---|
Chapter number | 108 |
Book title |
Transplant International
|
Published in |
Transplant International, January 1996
|
DOI | 10.1007/978-3-662-00818-8_108 |
Pubmed ID | |
Book ISBNs |
978-3-54-061024-3, 978-3-66-200818-8
|
Authors |
J. A. B. van der Hoeven, I. J. de Jong, R. F. E. Wolf, R. L. Kamman, R. J. Ploeg, Hoeven, J., Jong, I., Wolf, R., Kamman, R., Ploeg, R. |
Abstract |
Cold preservation of donor organs induces hypothermia-related tissue edema as a result of a reduced activity of the ATP-dependent sodium pump at low temperatures. Hypothermia-induced tissue edema occurs in kidney preservation and is a significant risk factor for delayed graft function (DGF) after transplantation. DGF remains a major problem in kidney transplantation and is significantly associated with preservation injury. The state of hydration of cold-stored organs can be assessed from a biopsy for determination of the wet/dry weight ratio. As a non-invasive method to determine tissue hydration MRI T1 and T2 relaxometry can be used. In this study we have compared changes in tissue hydration in UW-preserved porcine kidneys with increasing cold ischemia times (CIT) using wet/dry weight ratio and MR ralaxometry. The results of the two techniques were correlated to evaluate the use of MR relaxometry. Wet/dry weight ratios of the renal cortex decreased with prolonged CIT (P < 0.01) whereas those of the medulla did not change significantly. T1 values of the cortex decreased with prolonged CIT (P < 0.01). T2 values of the cortex showed a non-significant decline with increased CIT. No significant changes in T1 and T2 were found in the medulla. The correlation between T1 and the wet/dry weight ratio of the cortex was significant (P = 0.05, linear correlation coefficient 0.8698). We conclude that MR relaxometry can be a valuable noninvasive technique to assess tissue hydration in cadaveric donor kidneys before transplantation. |
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Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2022.
All research outputs
#3,868,198
of 23,213,531 outputs
Outputs from Transplant International
#297
of 1,686 outputs
Outputs of similar age
#5,743
of 79,981 outputs
Outputs of similar age from Transplant International
#1
of 2 outputs
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