Chapter title |
Effect of galectins on viral transmission.
|
---|---|
Chapter number | 26 |
Book title |
Galectins
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-1396-1_26 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1395-4, 978-1-4939-1396-1
|
Authors |
Michel Ouellet, Christian St-Pierre, Michel J Tremblay, Sachiko Sato, Michel J. Tremblay |
Abstract |
Recent reports suggest that some galectins bind to enveloped viruses. They include influenza virus, human immunodeficiency virus-1 (HIV-1), human T-cell leukemia virus-1 (HTLV-1), and Nipah virus. It is also suggested that the interaction between viruses and galectins influences viral attachment to their susceptible cells, affecting the viral infectivity. Our work suggests that galectin-1 increases the infectivity of HIV-1 and HTVL-1. Indeed, galectin-1 promotes the initial adsorption of HIV-1 to CD4(+) cells through its binding to viral envelope gp120 and facilitates HIV-1 infection in a manner that is dependent on its recognition of β-galactoside residues. Thus, as galectin-1 can be considered as a pattern recognition receptor, HIV-1 exploits this host factor to promote its transmission or replication. In this chapter, we describe methods used to investigate this potential role of galectins in HIV-1 infection as a case in point for future studies on galectin-virus interactions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 27% |
Professor > Associate Professor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Lecturer | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 4 | 27% |
Medicine and Dentistry | 3 | 20% |
Agricultural and Biological Sciences | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |