Chapter title |
Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings.
|
---|---|
Chapter number | 42 |
Book title |
Amine Oxidases: Function and Dysfunction
|
Published in |
Journal of neural transmission Supplementum, January 1994
|
DOI | 10.1007/978-3-7091-9324-2_42 |
Pubmed ID | |
Book ISBNs |
978-3-21-182521-1, 978-3-70-919324-2
|
Authors |
S Henriot, C Kuhn, R Kettler, M Da Prada, S. Henriot, C. Kuhn, R. Kettler, M. Da Prada, Henriot, S., Kuhn, C., Kettler, R., Da Prada, M. |
Abstract |
Ro 19-6327 (lazabemide, L), MDL 72974, selegiline, AGN 1135 and MDL 72145 were investigated for their MAO inhibitory effect in rat tissues in vitro. The selectivity of MAO-B inhibition of L, selegiline and MDL 72974 was also measured in vitro in human brain tissue as well as ex vivo in rat brain and liver after acute and subchronic administration. Of all compounds investigated L was the most selective for MAO-B inhibition under in vitro and ex vivo conditions. In volunteers, L completely but reversibly inhibited platelet MAO-B with a dose-dependent duration. Clinical trials with L are under way in both Alzheimer's and Parkinson's disease (PD). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 17% |
Student > Ph. D. Student | 2 | 17% |
Other | 1 | 8% |
Lecturer | 1 | 8% |
Student > Master | 1 | 8% |
Other | 2 | 17% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 25% |
Medicine and Dentistry | 2 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Chemical Engineering | 1 | 8% |
Psychology | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |