Chapter title |
Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart.
|
---|---|
Chapter number | 21 |
Book title |
Amine Oxidases: Function and Dysfunction
|
Published in |
Journal of neural transmission Supplementum, January 1994
|
DOI | 10.1007/978-3-7091-9324-2_21 |
Pubmed ID | |
Book ISBNs |
978-3-21-182521-1, 978-3-70-919324-2
|
Authors |
Dostert, P, Castelli, M G, Cicioni, P, Strolin Benedetti, M, P. Dostert, M. G. Castelli, P. Cicioni, M. Strolin Benedetti, Dostert, P., Castelli, M. G., Cicioni, P., Benedetti, M. Strolin |
Abstract |
This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker. Reboxetine was found totally to abolish the effect of tranylcypromine. Heart radioactivity levels after reboxetine and tranylcypromine were very similar to those found when tyramine was injected after reboxetine only. These results suggest that reboxetine might be advantageously combined with tranylcypromine, or any MAO inhibitor, in depressed patients unresponsive of either treatment given alone. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 1 | 33% |
Other | 1 | 33% |
Lecturer > Senior Lecturer | 1 | 33% |
Student > Master | 1 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 100% |
Agricultural and Biological Sciences | 1 | 33% |