Chapter title |
Effectiveness of Immunoprophylaxis in Suppressing Carriage of Neisseria Meningitidis in the Military Environment.
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Chapter number | 22 |
Book title |
Respiratory Virology and Immunogenicity
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Published in |
Advances in experimental medicine and biology, October 2014
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DOI | 10.1007/5584_2014_22 |
Pubmed ID | |
Book ISBNs |
978-3-31-910017-3, 978-3-31-910018-0
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Authors |
K Korzeniewski, A Skoczyńska, A Guzek, M Konior, A Chciałowski, I Waśko, M Markowska, E Zwolińska, K. Korzeniewski, A. Skoczyńska, A. Guzek, M. Konior, A. Chciałowski, I. Waśko, M. Markowska, E. Zwolińska, Korzeniewski, K., Skoczyńska, A., Guzek, A., Konior, M., Chciałowski, A., Waśko, I., Markowska, M., Zwolińska, E. |
Abstract |
Neisseria meningitidis, etiological factor of invasive meningococcal disease, is a human commensal that colonizes the nasopharynx. Colonization is usually asymptomatic, but it is a prerequisite for disease. Asymptomatic carriers are the major source of infection. In the present study, a survey of N. meningitidis carriage was conducted between January and March 2013 in a military unit in Poland. Single-time throat culture samples were collected from professional 559 soldiers (302 unvaccinated vs. 257 vaccinated individuals with the quadrivalent conjugate vaccine AC YW-135). Bacterial identification was performed with classic microbiological methods (culture, incubation, identification). Non-culture method (PCR) was used for confirmation of detected strains of N. meningitidis and determination of serogroups. We found 29 carriers in the group of unvaccinated soldiers (9.6 % of examined individuals) whereas among vaccinated soldiers only 3 persons were carriers of N. meningitidis (1.2 %). The most frequently identified serogroups among the carriers serving in the same military facility were serogroup B (28 %), followed by Y (25 %), and C (22 %). In conclusion, the initiation of mass vaccination with the quadrivalent conjugate vaccine ACYW-135 in the military environment seems an effective method of suppressing N. meningitidis carriage. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Brazil | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 23% |
Researcher | 4 | 15% |
Student > Postgraduate | 2 | 8% |
Student > Master | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 5 | 19% |
Unknown | 6 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 50% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Unspecified | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 27% |