Chapter 1 From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity

Chapter 2 Complex Systems Biology of Networks: The Riddle and the Challenge

Chapter 3 The Control Analysis of Signal Transduction

Chapter 4 MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic, and Genetic

Chapter 5 Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental–Computational Synergy

Chapter 6 Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling

Chapter 7 Moonlighting Function of the Tubulin Cytoskeleton: Macromolecular Architectures in the Cytoplasm

Chapter 9 Systems Biology Approaches to Cancer Energy Metabolism

Chapter 10 Network Dynamics in Cardiac Electrophysiology

Chapter 11 Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling

Chapter 12 Temporal Partitioning of the Yeast Cellular Network

Chapter 13 Systems Biology and Metabolic Engineering in Bacteria