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T Cell Activation by CD1 and Lipid Antigens

Overview of attention for book
Attention for Chapter 2: Architecture of CD1 proteins.
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Chapter title
Architecture of CD1 proteins.
Chapter number 2
Book title
T Cell Activation by CD1 and Lipid Antigens
Published in
Current topics in microbiology and immunology, December 2006
DOI 10.1007/978-3-540-69511-0_2
Pubmed ID
Book ISBNs
978-3-54-069510-3, 978-3-54-069511-0
Authors

Zajonc DM, Wilson IA, Zajonc, D. M., Wilson, I. A., D. M. Zajonc, I. A. Wilson

Abstract

The CD1 family of glycosylated cell surface receptors binds and presents lipid antigens for T cell recognition and activation. Crystal structures of CD1-lipid complexes reveal differences in the mode of presentation of lipids by CD1 group 1 (CDla, CDlb, and CDlc) and group 2 isoforms (CDld). For group 1, especially CDla and CD1b, the lipid backbone is anchored inside the hydrophobic binding grooves (lipid anchoring), whereas, for group 2 CDld, a precise hydrogen-bonding network positions the polar ligand headgroups in well-defined orientation at the T cell recognition surface (headgroup positioning). In addition, small, but important, structural changes occur on the surface of CDld upon binding of the potent invariant NKT cell agonist alpha-galactosylceramide due to increased polar interaction with the alphal and alpha2 helices. No such ligand-induced, conformational changes have yet been reported for any group 1 CD1 complexes, even upon binding of chemically diverse antigens, such as dual alkyl chain sphingolipids vs single alkyl chain lipopeptides. These structural data have already been successfully translated into the design of enhanced lipid activators of NKT cells and will likely continue for design of other chemotherapeutic agents or immunostimulatory compounds for a variety of immune-mediated diseases.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 6%
United States 1 6%
Switzerland 1 6%
Australia 1 6%
Unknown 13 76%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 41%
Student > Ph. D. Student 4 24%
Student > Bachelor 2 12%
Student > Doctoral Student 1 6%
Professor 1 6%
Other 2 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 47%
Chemistry 4 24%
Immunology and Microbiology 2 12%
Biochemistry, Genetics and Molecular Biology 2 12%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2022.
All research outputs
#7,402,457
of 22,638,310 outputs
Outputs from Current topics in microbiology and immunology
#200
of 671 outputs
Outputs of similar age
#41,848
of 153,004 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 8 outputs
Altmetric has tracked 22,638,310 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 671 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them