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Drug Delivery System

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Cover of 'Drug Delivery System'

Table of Contents

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    Book Overview
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    Chapter 1 Current Status and Future Prospects of Drug Delivery Systems
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    Chapter 2 A method for screening mitochondrial fusogenic envelopes for use in mitochondrial drug delivery.
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    Chapter 3 Ultrasound-Directed, Site-Specific Gene Delivery
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    Chapter 4 Synthesis of Thermoresponsive Polymers for Drug Delivery
  6. Altmetric Badge
    Chapter 5 Recombinant Stem Cells as Carriers for Cancer Gene Therapy
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    Chapter 6 Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications.
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    Chapter 7 Microneedle-Iontophoresis Combinations for Enhanced Transdermal Drug Delivery
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    Chapter 8 Polymer Nanoparticle-Based Controlled Pulmonary Drug Delivery
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    Chapter 9 Antibody labeling with radioiodine and radiometals.
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    Chapter 10 Self-Assembling Peptide-Based Delivery of Therapeutics for Myocardial Infarction
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    Chapter 11 Applications of Chitosan Nanoparticles in Drug Delivery
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    Chapter 12 A method for evaluating nanoparticle transport through the blood-brain barrier in vitro.
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    Chapter 13 Bacterial Systems for Gene Delivery to Systemic Tumors
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    Chapter 14 Synthesis of a Smart Nanovehicle for Targeting Liver
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    Chapter 15 Intranasal Delivery of Chitosan-siRNA Nanoparticle Formulation to the Brain.
  17. Altmetric Badge
    Chapter 16 Intrathecal Delivery of Analgesics
Attention for Chapter 12: A method for evaluating nanoparticle transport through the blood-brain barrier in vitro.
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Chapter title
A method for evaluating nanoparticle transport through the blood-brain barrier in vitro.
Chapter number 12
Book title
Drug Delivery System
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-4939-0363-4_12
Pubmed ID
Book ISBNs
978-1-4939-0362-7, 978-1-4939-0363-4
Authors

Daniela Guarnieri, Ornella Muscetti, Paolo A Netti, Paolo A. Netti, Guarnieri, Daniela, Muscetti, Ornella, Netti, Paolo A.

Abstract

Blood-brain barrier (BBB) represents a formidable barrier for many therapeutic drugs to enter the brain tissue. The development of new strategies for enhancing drug delivery to the brain is of great importance in diagnostics and therapeutics of central nervous system (CNS) diseases. In this context, nanoparticles are an emerging class of drug delivery systems that can be easily tailored to deliver drugs to various compartments of the body, including the brain. To identify, characterize, and validate novel nanoparticles applicable to brain delivery, in vitro BBB model systems have been developed. In this work, we describe a method to screen nanoparticles with variable size and surface functionalization in order to define the physicochemical characteristics underlying the design of nanoparticles that are able to efficiently cross the BBB.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Student > Ph. D. Student 2 20%
Professor 1 10%
Researcher 1 10%
Student > Postgraduate 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Pharmacology, Toxicology and Pharmaceutical Science 2 20%
Medicine and Dentistry 2 20%
Engineering 1 10%
Unknown 2 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2014.
All research outputs
#20,221,866
of 22,745,803 outputs
Outputs from Methods in molecular biology
#9,861
of 13,090 outputs
Outputs of similar age
#264,757
of 305,224 outputs
Outputs of similar age from Methods in molecular biology
#405
of 597 outputs
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So far Altmetric has tracked 13,090 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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