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Conditional Mutagenesis: An Approach to Disease Models

Overview of attention for book
Cover of 'Conditional Mutagenesis: An Approach to Disease Models'

Table of Contents

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    Book Overview
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    Chapter 1 Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases
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    Chapter 2 Cre/ loxP -Mediated Chromosome Engineering of the Mouse Genome
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    Chapter 3 Tetracycline-Controlled Genetic Switches
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    Chapter 4 Novel Gene Switches
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    Chapter 5 Improved Embryonic Stem Cell Technologies
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    Chapter 6 Gene Trap Mutagenesis
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    Chapter 7 RNA Interference in Mice
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    Chapter 8 Viral vectors: a wide range of choices and high levels of service.
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    Chapter 9 Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects
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    Chapter 10 Analysis of Mouse Development with Conditional Mutagenesis
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    Chapter 11 Conditional Mouse Models of Cancer
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    Chapter 12 Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models
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    Chapter 13 Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory
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    Chapter 14 A Novel Conditional Knockout Strategy Applied to Serotonin Receptors
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    Chapter 15 Conditional mouse models for Friedreich ataxia, a neurodegenerative disorder associating cardiomyopathy.
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    Chapter 16 Animal Models in Cardiovascular Diseases: New Insights from Conditional Models
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    Chapter 17 Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders
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    Chapter 18 Conditional mouse models to study developmental and pathophysiological gene function in muscle.
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    Chapter 19 Analysis of Calcium Channels by Conditional Mutagenesis
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    Chapter 20 Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins
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    Chapter 21 Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases
Attention for Chapter 8: Viral vectors: a wide range of choices and high levels of service.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

1 news outlet
2 patents


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Chapter title
Viral vectors: a wide range of choices and high levels of service.
Chapter number 8
Book title
Conditional Mutagenesis: An Approach to Disease Models
Published in
Handbook of experimental pharmacology, January 2007
DOI 10.1007/978-3-540-35109-2_8
Pubmed ID
Book ISBNs
978-3-54-035108-5, 978-3-54-035109-2

Osten P, Grinevich V, Cetin A, P. Osten, V. Grinevich, A. Cetin, Osten, P., Grinevich, V., Cetin, A.


Viruses are intracellular parasites with simple DNA or RNA genomes. Virus life revolves around three steps: infection of a host cell, replication of its genome within the host cell environment, and formation of new virions; this process is often but not always associated with pathogenic effects against the host organism. Since the mid-1980s, the main goal of viral vectorology has been to develop recombinant viral vectors for long-term gene delivery to mammalian cells, with minimal associated toxicity. Today, several viral vector systems are close to achieving this aim, providing stable transgenic expression in many different cell types and tissues. Here we review application characteristics of four vector systems, derived from adeno-associated viruses, adenoviruses, retroviruses and herpes simplex virus-1, for in vivo gene delivery. We discuss the transfer capacity of the expression vectors, the stability of their transgenic expression, the tropism of the recombinant viruses, the likelihood of induction of immunotoxicity, and the ease (or difficulty) of the virus production. In the end, we discuss applications of these vectors for delivery of three molecular systems for conditional mutagenesis, two for inducible transcriptional control of transgenic expression (the tet and the dimerizer systems), and the third one for inducible control of endogenous gene expression based on RNA interference.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 4%
United States 3 4%
United Kingdom 1 1%
Unknown 77 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 25%
Student > Ph. D. Student 15 18%
Student > Master 14 17%
Professor 6 7%
Student > Bachelor 5 6%
Other 12 14%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 49%
Neuroscience 10 12%
Biochemistry, Genetics and Molecular Biology 8 10%
Medicine and Dentistry 4 5%
Immunology and Microbiology 1 1%
Other 8 10%
Unknown 12 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2020.
All research outputs
of 22,755,127 outputs
Outputs from Handbook of experimental pharmacology
of 645 outputs
Outputs of similar age
of 157,349 outputs
Outputs of similar age from Handbook of experimental pharmacology
of 17 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 645 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,349 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.