Peptides for the New Millennium

Table of Contents

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   Book Overview
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   Chapter 1 Mimetic peptides, demanding enzymes and drug discovery
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   Chapter 2 Bruce W. Erickson: In memoriam
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   Chapter 3 Engineering of a cysteine-containing variant of quadrin, a protein containing the oligomerization site of the hepatitis delta antigen
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   Chapter 4 Characterization of betabellins 15D and 16D, designed beta-sandwich proteins that have amyloidogenic properties
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   Chapter 5 Design and synthesis of inhibitors of botulinum neurotoxin A and B metalloproteases
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   Chapter 6 Dimerization inhibitors of HIV-1 protease: Effective inhibition requires the cross-linking of non-identical peptides
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   Chapter 7 Backbone cyclic proteinomimetics derived from the arginine-rich domain of HIV-1 Tat and Rev proteins: One sequence, two conformations, two biological functions
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   Chapter 8 Synthesis of several O -glycopeptide analogs of enkephalin
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    Chapter 9 Investigating the role of turns in the folding of a predominantly β-sheet protein
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    Chapter 10 Receptor-bound conformations of integrin α IIb β 3 antagonists by 15 N-edited NMR spectroscopy
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    Chapter 11 Design, synthesis, and characterization of two core modules of bovine pancreatic trypsin inhibitor
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    Chapter 12 The fine tuning of high affinity and selective non-peptide agonists of the δ-opioid receptor via solution and solid-phase
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    Chapter 13 Cyclic dodecapeptides (LLLD) 3 form ion channels in lipid bilayers
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    Chapter 14 Synthesis and evaluation of potential affinity labels for opioid receptors
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    Chapter 15 Polyethyleneglycol-based chains of precise length for chemobodies
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    Chapter 16 N α -2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as an amino-protecting group and its application for peptide synthesis
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    Chapter 17 Nsc- and Fmoc-amino acids for automated solid-phase peptide synthesis: Comparative study of the stability in various conditions
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    Chapter 18 In situ generation of Fmoc amino acid chlorides for extremely difficult couplings to sterically hindered secondary amines in solid-phase peptide synthesis
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    Chapter 19 Evaluation of ivDde as a quasi-orthogonal protecting group for Fmoc solid-phase peptide synthesis
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    Chapter 20 N in -4-Nitrobenzenesulfonyl (Nbs): A new protecting group for the indole moiety of tryptophan
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    Chapter 21 Practical asymmetric synthesis of β-substituted glutamic acids
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    Chapter 22 Formation of substituted aromatic rings in amino acid systems via ruthenium activated S N Ar reactions
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    Chapter 23 O -Acetyl-L-homoserine: A versatile synthon for the synthesis of L-homoserine peptides and 3-amino-2-pyrrolidinones
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    Chapter 24 Asymmetric synthesis of free unusual β aminoacid esters via Yb(OTf) 3 -caalyzed C-C bond formation and simultaneous deprotection/purification
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    Chapter 25 High yield synthesis of heterocyclic β-substituted alanine derivatives
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    Chapter 26 Synthesis of (2 S ,4 R )-4-aminoethyl-L-Pro and (2S,4R)-4 -carboxymethyl-L-Pro from (2 S ,4 R )- N α -Boc-4-hydroxy-L-Pro methyl ester
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    Chapter 27 A highly effective method for synthesis of N ω -substituted arginines
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    Chapter 28 Diffusion phenomena and reactivity using polymer supports: A principal investigation
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    Chapter 29 Solid-phase peptide synthesis in the N → C direction
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    Chapter 30 Diisopropylethylamine salts for protected amino acids: Direct synthesis of peptides on solid-phase
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    Chapter 31 Synthesis of phosphorylated CRE BP1(19-106) amide using a phosphopeptide thioester prepared directly by an Fmoc solid-phase method
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    Chapter 32 Preparation of phosphohistidyl peptides via oxidative coupling of H -phosphonates
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    Chapter 33 Preparation and incorporation into small peptides and combinatorial libraries of phosphohistidine analogs for study of prokaryotic two-component signal transduction systems
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    Chapter 34 Synthesis of phosphonamides and thiophosphonamides by a one-pot activation-coupling-oxidation protocol
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    Chapter 35 Synthesis of phosphonopeptide and thiophosphonopeptide analogs as inhibitors of carboxypeptidase A
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    Chapter 36 Application of solid-phase Ellman’s reagent for preparation of disulfide-paired isomers of α-conotoxin SI
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    Chapter 37 Alternative solid-phase reagents for formation of intramolecular sulfur-sulfur bridges in peptides under mild conditions
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    Chapter 38 An evaluation of a novel safety catch linker for development of cyclic peptide libraries
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    Chapter 39 Solid-phase synthesis of peptide aldehydes by a Backbone Amide Linker (BAL) strategy
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    Chapter 40 Backbone Amide Linker (BAL) methodology to accommodate C -terminal hindered, unreactive, and/or sensitive modifications
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    Chapter 41 A new tartaric acid-based linker for the synthesis of C -terminal peptide α-oxo-aldehydes
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    Chapter 42 A new approach to the guanidinylation of peptides and peptidomimetics including aminoglycosides and related drugs
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    Chapter 43 Photoaffinity-labeled probes for the study of isoprenoid recognition sites
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    Chapter 44 Orthogonal methods for the synthesis of multiply labeled peptide probes and substrates
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    Chapter 45 Strategies for the synthesis of labeled peptides
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    Chapter 46 Orthogonal segment ligation
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    Chapter 47 Use of orthogonal ligation methods for the synthesis of a hetero peptide dendrimer
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    Chapter 48 Minimization of side reactions during removal of the formyl protecting group from the ε-amino group of lysine
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    Chapter 49 Mechanistic studies of an unusual amide bond scission
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    Chapter 50 Novel methods of making (amidated) peptides: Rapid gram quantities as intein fusions and ton quantities from fusion proteins in the milk of transgenic animals
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    Chapter 51 Process research toward scale-up and industrial preparation of RPR 109891 (Klerval ™ )
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    Chapter 52 Synthesis of cyclic hexapeptide core of antifungal drug candidates
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    Chapter 53 Large scale synthesis of a 27-mer: Identification, characterization and suppression of a diastereomer contaminant
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    Chapter 54 The chemical synthesis of agouti-related protein form C
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    Chapter 55 Chemical synthesis and characterization of the hypothalamic form of CART: CART(69–116), a new anorectic neuropeptide
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    Chapter 56 Application of hydrated salt as a source of essential water for enzymatic peptide synthesis in organic media
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    Chapter 57 Enzymatic synthesis of N -protected amino acid-steroid derivatives in organic solvent
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    Chapter 58 Peptide amidase-catalyzed C -terminal peptide amidation in a mixture of organic solvents
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    Chapter 59 Extending the utility of subtilisin-catalyzed peptide synthesis in organic solvents
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    Chapter 60 Backbone amide protection in solid-phase synthesis of peptide isosters derived from N -terminal γ-aldehydes
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    Chapter 61 An efficient preparation of O -succinimidyl carbamate derivatives from N -protected β-amino acids: Application to the synthesis of urea containing pseudopeptides and oligoureas
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    Chapter 62 Mimicry of peptide backbone and side-chain functions: Syntheses of 5- and 7-hydroxymethyl indolizidinone amino acids and indolizidinone amino dicarboxylate, constrained Ser-Pro and Glu-Pro surrogates
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    Chapter 63 A flexible regioselective method for bicyclization of peptides
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    Chapter 64 Stereoselective synthesis of dipeptidomimetics using chiral allylic aziridines
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    Chapter 65 Partially-modified retro-inverso βturn tetrapeptidomimetic
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    Chapter 66 Targeted libraries
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    Chapter 67 New technique for high-throughput synthesis of peptides, peptidomimetics and nonpeptide small organic molecule arrays
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    Chapter 68 Identification of miniproteins using cellulose-bound duotope scans
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    Chapter 69 Combinatorial peptide synthesis, NMR-aided screening and testing of low molecular weight RNA-ligands
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    Chapter 70 Synthetic peptide analogs compared with phage display
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    Chapter 71 Rapid parallel synthesis of 584 betides, peptides composed largely of beta-amino acids with side-chains not found in natural peptides
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    Chapter 72 SPOCC resins: Polar and chemically inert resins for organic synthesis and library enzyme assays
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    Chapter 73 Preparation and applications of a thioacetal handle for solid-phase synthesis
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    Chapter 74 “Traceless” solid-phase synthesis of benzimidazole libraries
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    Chapter 75 Synthesis of small cyclic peptides: An auxiliary approach to address the “difficult cyclization” problem
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    Chapter 76 On-resin cyclization of the cyclic depsipeptide callipeltin B
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    Chapter 77 Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from C α -functionalized amino acids
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    Chapter 78 Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development
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    Chapter 79 The usage of a β-sheet template with diversity points to generate libraries using the Irori method
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    Chapter 80 Solid-phase syntheses of libraries derived from 2-amino-4-carboxy-thiophenol moiety
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    Chapter 81 Solid-phase synthesis of thiol and thioether functions containing peptides and complex organic molecules
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    Chapter 82 Implant and transdermal innovations for peptide and protein delivery
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    Chapter 83 Loligomers: Multi-tasking intracellular peptide shuttles
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    Chapter 84 Utilization of cell-adhesion peptides to improve drug delivery
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    Chapter 85 Peptide shuttles for cytoplasmic delivery and nuclear targeting of chemotherapeutic agents
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    Chapter 86 Delivering peptides and peptidomimetics across membrane barriers: A prodrug approach
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    Chapter 87 Control of apoptosis by using small molecule regulators of Bcl-2 family proteins
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    Chapter 88 Bradykinin antagonists: Anti-cancer drugs for the new millennium?
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    Chapter 89 Development of the first CGRP-antagonist with nanomolar affinity
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    Chapter 90 DP IV-inhibitors: Potential antidiabetic drugs
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    Chapter 91 Synthesis and pharmacological activity of a new antagonist of the OP4 receptor
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    Chapter 92 Opioid dipeptide derivatives with a mixed μ antagonist/δ antagonist, partial μ agonist/δ antagonist or μ agonist/partial δ agonist profile
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    Chapter 93 Constrainedδ opioid peptides: Analogs of DPDPE and deltorphin I containing trimethylphenylalanine instead of phenylalanine
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    Chapter 94 Inhibition of α4γ1 integrin receptor interactions by bicyclic β-turn mimetics
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    Chapter 95 Recent progress in the field of α v -integrin antagonists
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    Chapter 96 Cytotoxic derivatives of luteinizing hormone-releasing hormone (LHRH): Synthesis and evaluation
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    Chapter 97 From peptide to non-peptide: The design of LHRH antagonist mimetics
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    Chapter 98 Identification of melanocortin-1 receptor selective small molecule agonists
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     Chapter 99 Identification and exploitation of structural foci that influence conformational mobility in somatostatin agonists and antagonists
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     Chapter 100 Phenyl piperidine-based orally active peptidomimetic agonists for somatostatin receptor subtype-2
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     Chapter 101 The design and synthesis of non-peptide somatostatin receptor agonists
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     Chapter 102 The discovery of orally-active pseudopeptide antagonists of the atrial natriuretic peptide clearance receptor
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     Chapter 103 Identification of new blockers of HIV-1 infectivity from synthetic combinatorial libraries
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     Chapter 104 Synthetic peptide-based reagents for blocking the entry and inactivation of HIV
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     Chapter 105 Synthesis of model systems of the complement inhibitors, complestatin and chloropeptin
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     Chapter 106 An intracellular approach for generating stable synthetic peptides and its potential applications
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     Chapter 107 Talking about TOAC: A novel electron spin resonance probe of peptide conformation
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     Chapter 108 Peptide folding induced by C α -methylated, chiral α-acids with a long aliphatic side chain
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     Chapter 109 Constrained amino acid analogs in de novo peptide design
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     Chapter 110 Peptide folding as a result of the incorporation of large-ring, cycloaliphatic C α,α -disubstituted glycines
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     Chapter 111 Importance of secondary structure specificity determinants in protein folding and stability
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     Chapter 112 A calorimetric study of the helix-coil transition using a side-chain bridged peptide that folds and unfolds cooperatively
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     Chapter 113 1 H-NMR structure of a 14-residue peptide incorporating a rigid, helix-stabilizing, (i, i+7)-side-chain bridge
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     Chapter 114 The design of heterodimeric coiled-coil domains for diagnostic display systems
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     Chapter 115 Structural investigations of designed glycosylated helix-loop-helix polypeptide motifs
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     Chapter 116 Effect of D-amino acid substitutions on amphipathic α-helical structure
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     Chapter 117 Metal induced assembly and folding of a triple stranded α-helical peptide
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     Chapter 118 Design of small symmetrical four-helix bundle proteins
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     Chapter 119 Cavitand templated de novo four-helix bundles
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     Chapter 120 Expanding the repertoire of helical bundles: Stabilization of five+ helical bundles
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     Chapter 121 Induction of α-helical protein-like molecular architecture by mono- and dialkyl hydrocarbon chains
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     Chapter 122 The peptide 3 10 -helix: Historical background and recent structural studies and applications
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     Chapter 123 The effects of stereochemistry and sequence on 5- t -butylproline type VI β-turn mimics
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     Chapter 124 Torsion angle based design of a βI turn adopting dipeptide (Ac-Aib-AzGly-NH 2 )
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     Chapter 125 Conformational analysis of azaproline and other turn inducers
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     Chapter 126 Strain-free disulfide bridge and stabilization of β-ribbon structures in short peptides
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     Chapter 127 Roles of proline residues in the structure and folding of a β-clam protein
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     Chapter 128 Self-assembly of synthetic peptides: Formation of amphipathic surfaces and head-to-tail self-assembly
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     Chapter 129 Rotamer number revealed as another parameter to gauge the quality of packing in folded proteins
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     Chapter 130 The side-chain classification of loops from high resolution protein crystal structures
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     Chapter 131 Dynamics and stability of partially folded and unfolded BPTI analogs
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     Chapter 132 Conformational studies with optical spectroscopy of peptides taken from hairpin sequences in the human chorionic gonadotropin β-subunit
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     Chapter 133 The mechanism of the propeptide-mediated folding of guanylyl cyclase activating peptides
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     Chapter 134 The a-factor lipopeptide pheromone of Saccharomyces cerevisiae : Synthesis, bioactivity, and biophysical analyses of position 4, 5 analogs
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     Chapter 135 Structural implications of a novel peptide dimerizer sequence when anchored to terminal ends of different peptide motifs
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     Chapter 136 Hydrogen-bonded self-assembled peptide nanotubes from cystine-based macrocycles containing bisurea or hydrocarbon segments
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     Chapter 137 Heterotrimeric collagen peptides as substrates of metalloproteinases
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     Chapter 138 Selective hydrolysis of triple-helical peptides by matrix metalloproteinases
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     Chapter 139 The stereoelectronic basis of collagen stability
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     Chapter 140 Contribution of mainchain-mainchain hydrogen bonds to the conformational stability of triple-helical collagen
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     Chapter 141 Density measurements and differential scanning calorimetry of collagen model peptides
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     Chapter 142 Design, synthesis and conformations of novel triple-helical collagen mimetic structures
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     Chapter 143 Effect of fluoro-substituted proline residues on the conformational stability of triple-helical collagen mimics
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     Chapter 144 Modulating the conformational stability of triple-helical collagen by chemical modification
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     Chapter 145 The assembly and analysis of collagen mimetics on a tris(2-aminoethyl) amine template
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     Chapter 146 Creating functional collagen peptide architectures on solid surfaces
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     Chapter 147 δ-Regions in proteins: Helices mispredicted as transmembrane segments by the threshold hydrophobicity requirement
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     Chapter 148 Dimerization of transmembrane helices studied using de novo designed hydrophobic peptides
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     Chapter 149 Transmembrane helix-helix recognition modeled by disulfide trapping in organic-aqueous solutions
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     Chapter 150 Determination of the relative positions between TMH V and VI of the μ opioid receptor using site-directed mutagenesis
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     Chapter 151 Biophysical studies on a transmembrane peptide of the Saccharomyces cerevisiae α-factor receptor
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     Chapter 152 Helix-helix interactions between transmembrane α-helices 3 and 4 within the cystic fibrosis transmembrane conductance regulator protein
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     Chapter 153 Chemical approach for evaluating role of the cysteine residues in pentameric phospholamban structure: Effect on sarcoplasmic reticulum Ca 2+ -ATPase
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     Chapter 154 Synthesis and biophysical characterization of highly hydrophobic transmembrane peptides
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     Chapter 155 Conformational studies of a detergent-bound transmembrane segment of the rat bradykinin receptor
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     Chapter 156 Gramicidin A: Structure and dynamic properties
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     Chapter 157 The proteome: Analysis and utility
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     Chapter 158 NMR analysis tools for the peptide sciences
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     Chapter 159 Studying structures attached to solid supports by high resolution magic angle spinning NMR (HR MAS NMR)
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     Chapter 160 Determination of specific peptide-micelle interactions using NMR spectroscopy
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     Chapter 161 Protein dynamics by hydrogen/deuterium exchange coupled to mass spectrometry: Purine nucleoside phosphorylase
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     Chapter 162 Fragmentation and sequencing of cyclic peptides by MALDI-PSD mass spectrometry
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     Chapter 163 LC/MS reversed-phase columns with excellent polypeptide resolution in low concentrations of TFA and acetic acid
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     Chapter 164 Application of single bead FTIR in the optimization of solid-phase combinatorial and parallel syntheses
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     Chapter 165 Analysis of local conformation within helical peptides via isotopeedited vibrational spectroscopy
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     Chapter 166 The role of zymogenicity in caspase activation: How to trigger programmed cell death
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     Chapter 167 Papain has a tolerance for D-stereochemistry at P 1 like caspases
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     Chapter 168 Positive and negative selectivity in protease evolution: Investigation of the specificities of plasmin, t-PA, u-PA, and PSA using substrate phage display
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     Chapter 169 Crystal structures of novel insect serine protease inhibitors complexed to bovine α-chymotrypsin
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     Chapter 170 Inhibitors of the bradykinin-degrading enzyme, aminopeptidase P
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     Chapter 171 Design and synthesis of AHHpA isosteres for the potential inhibition of methionine aminopeptidase-1
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     Chapter 172 A first subnanomolar and in vivo active inhibitor of aminopeptidase A (EC 3.4.11.7)
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     Chapter 173 A novel stable inhibitor of endopeptidases EC 3.4.24.15 and 3.4.24.16 potentiates bradykinin induced hypotension
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     Chapter 174 Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1)
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     Chapter 175 The synthesis of matrix metalloprotease inhibitor libraries using a hybrid mix/split parallel approach
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     Chapter 176 Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid-phase
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     Chapter 177 Selectivity in inhibition of proteolytic enzymes from Plasmodium falciparum
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     Chapter 178 Proteolytic splicing of Hb α-chain peptides with internal deletions
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     Chapter 179 In vivo detection of tumor associated protease activity using long circulating fluorescent labeled peptide substrates
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     Chapter 180 Novel inhibitors of the osteoclast specific cysteine protease, cathepsin K
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     Chapter 181 A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assay
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     Chapter 182 Pseudopeptide farnesyl-protein transferase inhibitors containing 5,5-dimethylthiazolidine-4-carboxylic acid
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     Chapter 183 Design of peptidomimetic farnesyltransferase inhibitors as anticancer agents
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     Chapter 184 Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substrates
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     Chapter 185 Biosynthesis and enzymatic characterization of human SKI-1 and the processing of its inhibitory prosegment
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     Chapter 186 Structural studies of peptide inhibitors bound to hepatitis C virus protease yield insights into the mechanism of action of the enzyme
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     Chapter 187 Optimization of a continuous assay for obtaining sensitive kinetic data on the inhibition of the HCV NS3 protease
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     Chapter 188 Molecular docking of peptide inhibitors to the hepatitis C virus NS3 protease
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     Chapter 189 Analysis of substrate specificity of HIV protease species
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     Chapter 190 Structure/activity studies of peptide library-based integrase inhibitors
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     Chapter 191 (Z)-Alkene phospho-Ser- cis -Pro substrate analog for Pin1, a phosphorylation-dependent peptidyl-prolyl isomerase
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     Chapter 192 C -terminal peptides as inhibitors and probes of mammalian ribonucleotide reductase
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     Chapter 193 Expressed protein ligation: A new tool for studying protein structure and function
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     Chapter 194 Combinatorial synthesis of de novo metalloproteins with tuned redox potential
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     Chapter 195 Catalysis of pyridoxal phosphate mediated transamination
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     Chapter 196 Synthetic steps toward de novo designed catalytic five helix bundle proteins
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     Chapter 197 HisH + -His reactive sites in catalytic four-helix bundle catalysts
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     Chapter 198 Semisynthetic approaches for the design of proteins with catalytic activity using fatty acid binding protein as a scaffold
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     Chapter 199 A peptide spacer in a fullerene (C 60 )-based donor-acceptor dyad
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     Chapter 200 Complexation of metal ions by pseudopeptides
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     Chapter 201 Photomodulation of conformational states in cyclic peptides by cis/trans isomerization of azobenzene
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     Chapter 202 Design and synthesis of two potent amide linked cyclic analogs of the hormone angiotensin II confirm the importance of ring cluster and relay system in its possible bioactive conformation
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     Chapter 203 Endothelin precursor isoforms: Structural basis for rational drug design of ECE inhibitors
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     Chapter 204 Rational development of an anti-HIV protein active at low picomolar concentrations
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     Chapter 205 Rational engineering of a miniprotein inhibitor of HIV-1 infectivity
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     Chapter 206 Design and synthesis of a chimeric TASP molecule as potential inhibitor in cell adhesion processes
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     Chapter 207 Design and synthesis of salt-insensitive cyclic α-defensins
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     Chapter 208 Conformational studies on three synthetic C -terminal fragments of the α subunit of a Gs protein
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     Chapter 209 Insights into glycoproteins: A structural motif for mucins from a glycopeptide
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     Chapter 210 Towards artificial antibodies: Protein surface recognition by synthetic receptors
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     Chapter 211 Synthetic oxytocin receptors prepared by molecular imprinting
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     Chapter 212 Peptide mimetics of erythropoietin are powerful probes of receptor activation mechanisms
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     Chapter 213 Recombinant, C -terminally tagged forms of the human insulin receptor extracellular domain retain insulin binding ability
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     Chapter 214 New dimensions in the design of potent and receptor selective melanotropin analogs
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     Chapter 215 Design and biological activity of new high-affinity ligands for the urokinase-type plasminogen activator receptor (CD87)
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     Chapter 216 Total synthesis of maxadilan and its disulfide isomers, and structural requirements for binding to the PACAP type 1 receptor
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     Chapter 217 Solid state conformation of serine 3 DPDPE
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     Chapter 218 The cation-π interaction: From structural biology to neuroreceptor binding sites
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     Chapter 219 Chemoenzymatic synthesis of lipidated peptide and protein conjugates: Tools for the study of biological signal transduction
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     Chapter 220 Bone-targeted, nonpeptide inhibitors of the Src SH2 domain: Structure-based design and structure-activity relationships
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     Chapter 221 Nonpeptide inhibitors of the pp60 c-src (Src) SH2 domain: Discovery of a novel phosphotyrosine mimetic
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     Chapter 222 Phosphotyrosyl peptides targeted to the SH2 domain are potent inhibitors of the kinase activity of pp60 c-src
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     Chapter 223 Novel phosphotyrosyl mimetics for the preparation of potent small molecule Grb2 SH2 domain inhibitors
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     Chapter 224 High affinity nonphosphorylated cyclic peptide inhibitors of Grb2-SH2/growth factor receptor interactions
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     Chapter 225 NMR based solution structure and dynamics of a nonphosphorylated cyclic peptide inhibitor for the Grb2 SH2 domain
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     Chapter 226 Potent Grb2-SH2 antagonists containing asparagine mimetics
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     Chapter 227 Design and synthesis of a new tyrosine analog having χ 1 and χ 2 angles constrained to values observed for an SH2 domain-bound phosphotyrosyl residue
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     Chapter 228 Synthesis of more rigid consolidated ligands for the dual Src homology domain SH(32) of Abelson: Strategies to achieve higher affinities
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     Chapter 229 A common ligand-binding site in G-protein coupled receptors
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     Chapter 230 Bound conformations for ligands of G-protein coupled receptors
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     Chapter 231 Modeling of secretin-like G protein coupled receptors
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     Chapter 232 Synthetic peptides of the α subunit of G s protein inhibit receptor mediated adenylyl cyclase
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     Chapter 233 Point mutation in TM6 of the melanocortin-4 receptor results in agonist activity of the MC4R antagonist SHU9119
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     Chapter 234 Modulation of NK-2 receptor associated G-protein signaling by alteration of the aromatic residue at position six in neurokinin A analogs
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     Chapter 235 Peptide mimetics of receptor extracellular domains modulate signal transduction by P2Y 2 receptors
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     Chapter 236 Molecular characterization of the interaction between parathyroid hormone and its receptor
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     Chapter 237 Glucagon receptor causes glucagon-dependent activation of Erk1/2 in H22 stable cell lines
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     Chapter 238 Peptides for elucidating the signal tranduction pathways of CTLA-4 and CD28
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     Chapter 239 Design and synthesis of inhibitors of the protein tyrosine phosphatase, SHP-2
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     Chapter 240 Efficacy: What is it, and why you should care
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     Chapter 241 Development of a chemical microarray technology
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     Chapter 242 Cyclopentapeptides as conformational templates for validating three dimensional models of pharmacophores
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     Chapter 243 Novel opioid peptides as kappa opioid receptor antagonists
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     Chapter 244 H-Tyr-Tic-Phe-OH related δ opioid agonists and antagonists have similar receptor-bound conformations but different pharmacophores
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     Chapter 245 Mapping the binding epitopes of IGF-1 and a phage-library derived peptide that inhibits IGFBP-1 binding to insulin-like growth factor
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     Chapter 246 Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1: Biological activity, NMR and conformational analysis of D-amino acid substituted analogs
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     Chapter 247 Stimulation and suppression of the immune response and hemopoiesis by novel natural and synthetic peptides
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     Chapter 248 Relating peptide presentation and biological response through supported films of peptide amphiphiles
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     Chapter 249 Studying the influence of prolyl amide geometry on bioactivity with 5- t -butylproline oxytocin analogs
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     Chapter 250 The effect of disulfide bond replacement by a methylenedithioether bond on the biological activity of oxytocin and deaminooxytocin
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     Chapter 251 Increased serum stability of neurotensin analogs containing arginine mimics
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     Chapter 252 Synthesis and pharmacological evaluation of a new series of bombesin analogs
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     Chapter 253 Molecular pharmacology of vasopressin receptors
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     Chapter 254 Discovery of new lead for the design of antagonists of human vasopressin(VP)V 1b receptor
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     Chapter 255 Biological studies on chimeric dimers of oxytocin and the V 2 -antagonist, d(CH 2 ) 5 [D-Ile 2 , Ile 4 ]arginine vasopressin
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     Chapter 257 Homology-based analysis of thrombin receptors