Chapter title |
Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis
|
---|---|
Chapter number | 22 |
Book title |
Chromothripsis
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7780-2_22 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7779-6, 978-1-4939-7780-2
|
Authors |
Kevin Yauy, Vincent Gatinois, Thomas Guignard, Satish Sati, Jacques Puechberty, Jean Baptiste Gaillard, Anouck Schneider, Franck Pellestor |
Abstract |
Apparition of next-generation sequencing (NGS) was a breakthrough on knowledge of genome structure. Bioinformatic tools are a key point to analyze this huge amount of data from NGS and characterize the three-dimensional organization of chromosomes. This chapter describes usage of different browsers to explore publicly available online data and to search for possible 3D chromatin changes involved during complex chromosomal rearrangements as chromothripsis. Their pathogenic impact on clinical phenotype and gene misexpression can also be evaluated with annotated databases. |
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