Chapter title |
Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane.
|
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Chapter number | 23 |
Book title |
Bioactive Components of Human Milk
|
Published in |
Advances in experimental medicine and biology, January 2001
|
DOI | 10.1007/978-1-4615-1371-1_23 |
Pubmed ID | |
Book ISBNs |
978-1-4613-5521-2, 978-1-4615-1371-1
|
Authors |
J A Peterson, C D Scallan, R L Ceriani, M Hamosh, Peterson, Jerry A., Scallan, Ciaran D., Ceriani, Roberto L., Hamosh, Margit, Jerry A. Peterson, Ciaran D. Scallan, Roberto L. Ceriani, Margit Hamosh |
Abstract |
The MUC1 mucin, lactadherin, and butyrophilin are 3 major components of the human milk fat globule membrane. The mucin inhibits binding of S-fimbriated Escherichia coli to buccal epithelial cells, and lactadherin prevents symptomatic rotavirus infection in breast-fed infants. Butyrophilin has been suggested to be a structural component of the human milk fat globule (HMFG) membrane and to have receptor functions, but has no known anti-infective activity. These HMFG glycoproteins also are present in skimmed milk, possibly associated with phospholipid micelles, while mucin is also in a soluble form. Mucin and lactadherin resist digestion in the stomach of milk-fed infants, while butyrophilin is rapidly degraded. The MUC1 mucin is an extended rod-like structure forming part of the glycocalyx on the surface of many epithelial cells and membranes of milk, and may act as a decoy for binding of infective agents. The extracellular segment of butyrophilin has homology to Ig superfamily receptors and an intracellular domain with homology to developmentally regulated proteins. Lactadherin is a laterally mobile cell adhesion molecule that interacts with integrins and has a novel means of membrane-association involving specific binding to phosphatidylserine. The structural and functional aspects of these glycoproteins are discussed with regard to their role in human milk for breast-fed infants. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 28% |
Student > Ph. D. Student | 7 | 19% |
Other | 5 | 14% |
Student > Master | 3 | 8% |
Student > Doctoral Student | 2 | 6% |
Other | 3 | 8% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 28% |
Agricultural and Biological Sciences | 7 | 19% |
Medicine and Dentistry | 3 | 8% |
Immunology and Microbiology | 3 | 8% |
Nursing and Health Professions | 1 | 3% |
Other | 6 | 17% |
Unknown | 6 | 17% |