Chapter title |
HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26.
|
---|---|
Chapter number | 24 |
Book title |
Cellular Peptidases in Immune Functions and Diseases
|
Published in |
Advances in experimental medicine and biology, January 1997
|
DOI | 10.1007/978-1-4757-9613-1_24 |
Pubmed ID | |
Book ISBNs |
978-1-4757-9615-5, 978-1-4757-9613-1
|
Authors |
A Valenzuela, J Blanco, C Callebaut, E Jacotot, C Lluis, A G Hovanessian, R Franco, Valenzuela, A, Blanco, J, Callebaut, C, Jacotot, E, Lluis, C, Hovanessian, A G, Franco, R, Agustin Valenzuela, Julià Blanco, Christian Callebaut, Etienne Jacotot, Carmen Lluis, Ara G. Hovanessian, Rafael Franco, Valenzuela, Agustin, Blanco, Julià, Callebaut, Christian, Jacotot, Etienne, Lluis, Carmen, Hovanessian, Ara G., Franco, Rafael |
Abstract |
CD26, known to be the adenosine deaminase (ADA) binding protein, has been implicated in HIV infection. In human B and T cell lines we show that, irrespective of CD4 expression, 125I-labeled ADA binding to CD26 is inhibited by recombinant soluble HIV-1 envelope glycoprotein gp120 and by HIV-1 infectious particles. Overlapping synthetic peptides covering the entire gp120 sequence were tested to map the region in gp120 responsible for ADA binding inhibition. Only peptides in the C3 region significantly inhibited the binding of ADA to CD26. These results indicate that a specific function of gp120 is the inhibition of ADA binding to CD26 in both CD4+ and CD4- cells. Since the interaction ecto-ADA/CD26 is required for the activation of T cells, it remains possible that HIV particle-mediated blockade of ecto-ADA/CD26 interaction may have significant consequences in the pathogenesis of AIDS disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 33% |
Professor | 2 | 17% |
Student > Doctoral Student | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |
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Social Sciences | 1 | 8% |
Neuroscience | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |