Chapter 1 Introduction and historical overview

Chapter 2 Phytochemistry

Chapter 3 St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies

Chapter 4 Effects on transmitter uptake and their cellular and molecular basis

Chapter 5 Modulation of neurotransmitter release and metabolism

Chapter 6 Efficacy in behavioural models of antidepressant activity

Chapter 8 Hyperforin and efficacy in animal models for anxiety and cognition

Chapter 9 Pharmacokinetics and biopharmaceuticals

Chapter 10 Clinical efficacy in depression

Chapter 11 Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression

Chapter 12 Side effects and drug interactions

Chapter 13 Endocrinology of St. John’s Wort extract