Title |
Terminal elimination plasma half-life of Δ1-tetrahydrocannabinol (Δ1-THC) in heavy users of marijuana
|
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Published in |
European Journal of Clinical Pharmacology, May 1989
|
DOI | 10.1007/bf00679783 |
Pubmed ID | |
Authors |
E. Johansson, M. M. Halldin, S. Agurell, L. E. Hollister, H. K. Gillespie |
Abstract |
The terminal elimination half-life of delta 1-tetrahydrocannabinol (delta 1-THC) was investigated in eight men who were heavy users of marijuana. A stable isotope assay, following smoking deuterium-labeled delta 1-THC, was used to determine plasma concentrations. In two additional users plasma levels were followed after administration of unlabeled delta 1-THC. The subjects were asked to smoke a "loading dose" of 56 mg delta 1-THC during two days and then abstain from all marijuana use for 4 weeks. The pharmacokinetic behavior was consistent with a multicompartment model with a mean plasma elimination half-life of delta 1-THC of 4.3 days when concentrations were followed for 10-15 days after smoking. In the two subjects with detectable plasma levels during 4 weeks, half-lives of 9.6 and 12.6 days was obtained. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
United States | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 19% |
Student > Ph. D. Student | 8 | 19% |
Student > Bachelor | 7 | 17% |
Student > Master | 4 | 10% |
Other | 4 | 10% |
Other | 3 | 7% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 24% |
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Chemistry | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 6 | 14% |
Unknown | 9 | 21% |