Chapter title |
Regulation of CTL Infiltration Within the Tumor Microenvironment
|
---|---|
Chapter number | 3 |
Book title |
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-67577-0_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-967575-6, 978-3-31-967577-0
|
Authors |
Sarah E. Church, Jérôme Galon |
Abstract |
The tumor microenvironment consists of a complex milieu of cells and factors that maintain equilibrium between tumor progression and destruction. Characterization of the immune contexture in primary tumors has consistently shown that T lymphocytes are an integral predictor of improved clinical outcome. This is notably true in colorectal carcinoma where high densities of cytotoxic or memory T lymphocytes in the invasive margin and the center of the primary tumor predict better patient survival, a measure termed Immunoscore. Since a high Immunoscore and pre-existing adaptive immune response are significantly correlated with improved clinical outcome, it is essential to understand the mechanisms underlying functional T lymphocyte infiltration into the tumor. The ability of cytolytic and memory T lymphocytes to migrate into tumors is regulated by multiple strategies including T lymphocyte help, homing factors, cytokines, tumor genotype, angiogenesis, lymphangiogenesis, and neurological signals. This chapter will discuss the predominant factors that mediate T-lymphocyte infiltration into tumors and how analysis of these biomarkers determine patients' disease-related survival and predicts response to cancer therapy. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 39 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 7 | 18% |
Student > Doctoral Student | 5 | 13% |
Researcher | 5 | 13% |
Student > Bachelor | 4 | 10% |
Professor | 3 | 8% |
Other | 6 | 15% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 26% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Immunology and Microbiology | 6 | 15% |
Agricultural and Biological Sciences | 4 | 10% |
Economics, Econometrics and Finance | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 28% |