| Chapter title |
Photoimmunology and Multiple Sclerosis.
|
|---|---|
| Chapter number | 359 |
| Book title |
Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments
|
| Published in |
Current topics in behavioral neurosciences, January 2015
|
| DOI | 10.1007/7854_2014_359 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-925541-5, 978-3-31-925543-9
|
| Authors |
Felix Marsh-Wakefield, Scott N Byrne, Scott N. Byrne |
| Abstract |
The ultraviolet (UV) radiation contained in sunlightSunlight is a powerful immune suppressant. While exposure to UV is best known for its ability to cause skin cancer, it is also associated with protection against a range of autoimmune diseases, particularly multiple sclerosis (MS). Although the precise mechanism by which sunlightSunlight affords protection from MS remains to be determined, some have hypothesised that UV immunosuppression explains the "latitude-gradient effect" associated with MS. By stimulating the release of soluble factors in exposed skin, UV activates immune suppressive pathways that culminate in the induction of regulatory cellsRegulatory cells in distant tissues. Each and every one of the immune suppressive cells and molecules activated by UV exposure are potential targets for treating and preventing MS. A thorough understanding of the mechanisms involved is therefore required if we are to realise the therapeutic potential of photoimmunology. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 28% |
| Researcher | 4 | 16% |
| Professor > Associate Professor | 2 | 8% |
| Student > Doctoral Student | 1 | 4% |
| Other | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 8 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 32% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Agricultural and Biological Sciences | 2 | 8% |
| Immunology and Microbiology | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 9 | 36% |