Chapter title |
Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment
|
---|---|
Chapter number | 5 |
Book title |
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-67577-0_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-967575-6, 978-3-31-967577-0
|
Authors |
Jonathan M. Pitt, Guido Kroemer, Laurence Zitvogel |
Abstract |
The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance. On the other hand, stimuli that cause immunogenic death of cancer cells can induce an effective anti-tumor immune response. In this chapter we discuss different forms of cell death in the tumor microenvironment, and how these interact with host immune cells to impact tumor progression and cancer therapy. We focus on how cancer cells hijack aspects of cell death to promote tumor survival, and how anti-cancer treatments that activate immunogenic death modalities give strong and durable clinical efficacy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 9 | 12% |
Student > Ph. D. Student | 8 | 11% |
Student > Master | 8 | 11% |
Student > Bachelor | 5 | 7% |
Researcher | 5 | 7% |
Other | 12 | 16% |
Unknown | 29 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 12% |
Immunology and Microbiology | 9 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Agricultural and Biological Sciences | 6 | 8% |
Other | 8 | 11% |
Unknown | 30 | 39% |