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Histamine in Inflammation

Overview of attention for book
Attention for Chapter 10: Histamine in Neurotransmission and Brain Diseases.
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2 CiteULike
2 Connotea
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Chapter title
Histamine in Neurotransmission and Brain Diseases.
Chapter number 10
Book title
Histamine in Inflammation
Published in
Advances in experimental medicine and biology, June 2011
DOI 10.1007/978-1-4419-8056-4_10
Pubmed ID
Book ISBNs
978-1-4419-8055-7, 978-1-4419-8056-4

Nuutinen S, Panula P, Saara Nuutinen, Pertti Panula, Nuutinen, Saara, Panula, Pertti


Apart from its central role in the mediation of allergic reactions, gastric acid secretion and inflammation in the periphery, histamine serves an important function as a neurotransmitter in the central nervous system. The histaminergic neurons originate from the tuberomamillary nucleus of the posterior hypothalamus and send projections to most parts of the brain. The central histamine system is involved in many brain functions such as arousal, control of pituitary hormone secretion, suppression of eating and cognitive functions. The effects of neuronal histamine are mediated via G-protein-coupled H(1)-H(4) receptors. The prominent role of histamine as a wake-promoting substance has drawn interest to treat sleep-wake disorders, especially narcolepsy, via modulation of H(3) receptor function. Post mortem studies have revealed alterations in histaminergic system in neurological and psychiatric diseases. Brain histamine levels are decreased in Alzheimer's disease patients whereas abnormally high histamine concentrations are found in the brains of Parkinson's disease and schizophrenic patients. Low histamine levels are associated with convulsions and seizures. The release of histamine is altered in response to different types of brain injury: e.g. increased release of histamine in an ischemic brain trauma might have a role in the recovery from neuronal damage. Neuronal histamine is also involved in the pain perception. Drugs that increase brain and spinal histamine concentrations have antinociceptive properties. Histaminergic drugs, most importantly histamine H(3) receptors ligands, have shown efficacy in many animal models of the above-mentioned disorders. Ongoing clinical trials will reveal the efficacy and safety of these drugs in the treatment of human patients.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Mexico 1 <1%
Japan 1 <1%
Unknown 159 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 30 18%
Researcher 23 14%
Student > Master 23 14%
Student > Ph. D. Student 14 9%
Student > Doctoral Student 8 5%
Other 23 14%
Unknown 42 26%
Readers by discipline Count As %
Medicine and Dentistry 22 13%
Neuroscience 18 11%
Agricultural and Biological Sciences 14 9%
Chemistry 12 7%
Pharmacology, Toxicology and Pharmaceutical Science 11 7%
Other 34 21%
Unknown 52 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2024.
All research outputs
of 25,282,542 outputs
Outputs from Advances in experimental medicine and biology
of 5,279 outputs
Outputs of similar age
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Outputs of similar age from Advances in experimental medicine and biology
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Altmetric has tracked 25,282,542 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,279 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,945 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.