Mitochondrial DNA and Diseases
Springer, Singapore
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Timeline
Mendeley readers
| Chapter title |
Roles of Mitochondrial DNA Signaling in Immune Responses
|
|---|---|
| Chapter number | 4 |
| Book title |
Mitochondrial DNA and Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-6674-0_4 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-106673-3, 978-9-81-106674-0
|
| Authors |
Lingyan Wang, Michael N. Liebmen, Xiangdong Wang |
| Abstract |
Mitochondrial DNA (mtDNA) plays an important role in immune responses during the evolution. The present chapter systemically describes its role on immune-related diseases and its interaction on immune responses. It is important to explore the main function and mechanisms of mtDNA in immune responses by which mtDNA regulates the signaling pathways of Toll-like receptor 9, autophagy, and STING. There are potentials to discover therapeutic targets of mtDNA in immune diseases and inflammation. It will be more exciting if the CRISPR-Cas9 method can be applied for mtDNA gene editing to cure diseases and provide a novel insight of mtDNA in immune responses as well as new therapies. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Researcher | 3 | 16% |
| Student > Bachelor | 3 | 16% |
| Professor > Associate Professor | 3 | 16% |
| Student > Doctoral Student | 2 | 11% |
| Other | 1 | 5% |
| Unknown | 3 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 37% |
| Medicine and Dentistry | 5 | 26% |
| Neuroscience | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Unknown | 5 | 26% |