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TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Overview of attention for book
Cover of 'TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction: How We Encountered TCTP and Our Purpose in Studying It
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    Chapter 2 Structural Insights into TCTP and Its Interactions with Ligands and Proteins
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    Chapter 3 Structure-Function Relationship of TCTP
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    Chapter 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation
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    Chapter 5 Current Understanding of the TCTP Interactome
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    Chapter 6 Role and Fate of TCTP in Protein Degradative Pathways
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    Chapter 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development
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    Chapter 8 Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies
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    Chapter 9 Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms
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    Chapter 10 Tctp in Neuronal Circuitry Assembly
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    Chapter 11 Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation
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    Chapter 12 The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radiation-Induced DNA Damage
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    Chapter 13 TCTP Has a Crucial Role in the Different Stages of Prostate Cancer Malignant Progression
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    Chapter 14 Role of TCTP for Cellular Differentiation and Cancer Therapy
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    Chapter 15 Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment
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    Chapter 16 History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy
Attention for Chapter 8: Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies
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Chapter title
Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies
Chapter number 8
Book title
TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease
Published in
Results and problems in cell differentiation, January 2017
DOI 10.1007/978-3-319-67591-6_8
Pubmed ID
29149408
Book ISBNs
978-3-31-967590-9, 978-3-31-967591-6
Authors

Kwang-Wook Choi, Sung-Tae Hong, Thao Phuong Le

Abstract

Regulation of cell growth and proliferation is crucial for development and function of organs in all animals. Genetic defects in growth control can lead to developmental disorders and cancers. Translationally controlled tumor protein (TCTP) is a family of evolutionarily conserved proteins implicated in cancer. Recent studies have revealed multiple roles of TCTP in diverse cellular events, but TCTP functions in vivo are poorly understood in vertebrate systems. We have used Drosophila melanogaster, the fruit fly, as a model organism for genetic dissection of Tctp function. Our studies have shown that Tctp is essential for organ development by regulating growth signaling. Furthermore, it is required for genome stability by promoting DNA repair and chromatin remodeling in the nucleus. Thus, Tctp acts as a multifaceted cytosolic and nuclear factor for regulating organ growth and genome stability. In this chapter, we describe an overview of our findings on Tctp functions in Drosophila and discuss their implications in cancer.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 20%
Student > Master 1 20%
Unknown 3 60%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 20%
Immunology and Microbiology 1 20%
Unknown 3 60%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2019.
All research outputs
#17,920,654
of 23,008,860 outputs
Outputs from Results and problems in cell differentiation
#122
of 217 outputs
Outputs of similar age
#294,432
of 421,267 outputs
Outputs of similar age from Results and problems in cell differentiation
#21
of 39 outputs
Altmetric has tracked 23,008,860 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 217 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.

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