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Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

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Cover of 'Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy'

Table of Contents

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    Book Overview
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    Chapter 1 Platinum Compounds: The Culmination of the Era of Cancer Chemotherapy
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    Chapter 2 Studies on New Platinum Compounds
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    Chapter 3 Assessment of the In Vivo Antiproliferative Activity of a Novel Platinum Particulate Pharmacophore
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    Chapter 4 Nanocapsules of Platinum-Based Anticancer Drugs
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    Chapter 5 The Design and Development of the Tumor-Targeting Nanopolymer Dach Platinum Conjugate AP5346 (Prolindac™)
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    Chapter 6 In vitro Anti-proliferative Effects of ProLindac™, a Novel Dach-Platinum-Linked Polymer Compound, as a Single Agent and in Combination with Other Anti-cancer Drugs
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    Chapter 7 Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes
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    Chapter 8 Ruthenium Drugs for Cancer Chemotherapy: An Ongoing Challenge to Treat Solid Tumours
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    Chapter 9 X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex
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    Chapter 10 Osmium Arenes: A New Class of Potential Anti-cancer Agents
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    Chapter 11 Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells
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    Chapter 12 CTR1 as a Determinant of Platinum Drug Transport
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    Chapter 13 Regulation of the Export of Platinum-Containing Drugs by the Copper Efflux Transporters ATP7A and ATP7B
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    Chapter 14 Altered Localization of Transport Proteins Associated with Cisplatin Resistance
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    Chapter 15 How to Overcome Cisplatin Resistance Through Proton Pump Inhibitors
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    Chapter 16 Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
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    Chapter 17 Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action
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    Chapter 18 Structural and Mechanistic Studies of Anticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding
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    Chapter 19 Platinum Drugs and DNA Repair: Lessons from the NCI Panel and Clinical Correlates
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    Chapter 20 Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts
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    Chapter 21 Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest
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    Chapter 22 Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy
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    Chapter 23 CHK2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance
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    Chapter 24 Modulation of Survival Pathways in Ovarian Carcinoma Cells Resistant to Platinum Compounds
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    Chapter 25 Paraptotic Cell Death Induced by the Thioxotriazole Copper Complex A0: A New Tool to Kill Apoptosis-Resistant Cancer Cells
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    Chapter 26 Platinum Compounds and Radiation
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    Chapter 27 Treating Cisplatin-Resistant Cancer: A Systematic Analysis of Oxaliplatin or Paclitaxel Salvage Chemotherapy
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    Chapter 28 Platinum Compounds in Lung Cancer: Current Status
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    Chapter 29 Is Lipoplatinum Monotherapy an Active Alternative in Second Line Treatment of Metastatic Non–Small Cell Lung Cancer? A Phase II Trial
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    Chapter 30 Combining Platinums in Gastric Cancer
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    Chapter 31 Oxaliplatin-Based Chemotherapy for Colon Cancer
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    Chapter 32 First-Line Systemic Chemotherapy with Folfoxiri Followed by Radical Surgical Resection of Metastases for the Treatment of Unresectable Metastatic Colorectal Cancer Patients
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    Chapter 33 Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin
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    Chapter 34 The Role of Platins in Newly Diagnosed Endometrial Cancer
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    Chapter 35 Platinum Compounds: Key Ingredients in Ovarian Cancer Treatment and Strategies
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    Chapter 36 Intraperitoneal Chemotherapy: An Important Strategy in Ovarian Cancer Treatment
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    Chapter 37 Novel Strategies for Enhancing the Efficacy of Intraperitoneal Chemotherapy for Patients with Ovarian Cancer
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    Chapter 38 Laparoscopically Assisted Heated Intra-Operative Intraperitoneal Chemotherapy (HIPEC): Technical Aspect and Pharmacokinetics Data
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    Chapter 39 Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity
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    Chapter 40 Peripheral Neurotoxicity of Platinum Compounds
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    Chapter 41 Platinum Drugs in Children with Cancer
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    Chapter 42 Optimising Carboplatin Dose using Patient Characteristics and Therapeutic Drug Monitoring
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Title
Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
Published by
Humana Press, Totowa, NJ, December 2008
DOI 10.1007/978-1-60327-459-3
ISBNs
978-1-60327-458-6, 978-1-60327-459-3, 978-1-4939-5710-1
Editors

Andrea Bonetti, Roberto Leone, Franco M. Muggia, Stephen B. Howell

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
United States 1 1%
France 1 1%
Canada 1 1%
Unknown 64 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 23%
Researcher 14 20%
Student > Master 8 12%
Student > Bachelor 5 7%
Student > Doctoral Student 4 6%
Other 14 20%
Unknown 8 12%
Readers by discipline Count As %
Chemistry 36 52%
Agricultural and Biological Sciences 11 16%
Biochemistry, Genetics and Molecular Biology 7 10%
Medicine and Dentistry 4 6%
Nursing and Health Professions 1 1%
Other 1 1%
Unknown 9 13%