Cancer Susceptibility

Chapter 1 The Identification of Colon Cancer Susceptibility Genes by Using Genome-Wide Scans

Chapter 2 Prioritizing Candidate Genetic Modifiers of BRCA1 and BRCA2 Using a Combinatorial Analysis of Global Expression and Polymorphism Association Studies of Breast Cancer

Chapter 3 Microarray-Based Comparative Genomic Hybridization (Array-CGH) as a Useful Tool for Identifying Genes Involved in Glioblastoma (GB)

Chapter 4 Multiplex Amplifiable Probe Hybridization (MAPH) Methodology as an Alternative to Comparative Genomic Hybridization (CGH)

Chapter 5 Utilizing Saccharomyces Cerevisiae to Identify Aneuploidy and Cancer Susceptibility Genes

Chapter 6 Computational Identification of Cancer Susceptibility Loci

Chapter 7 Digital Candidate Gene Approach (DigiCGA) for Identification of Cancer Genes

Chapter 8 The Use of Denaturing High Performance Liquid Chromatography (DHPLC) for Mutation Scanning of Hereditary Cancer Genes

Chapter 9 Enhanced Mismatch Mutation Analysis: Simultaneous Detection of Point Mutations and Large Scale Rearrangements by Capillary Electrophoresis, Application to BRCA1 and BRCA2

Chapter 10 Economical Protocol for Combined Single-Strand Conformation Polymorphism and Heteroduplex Analysis on a Standard Capillary Electrophoresis Apparatus

Chapter 11 Mutational Screening of hMLH1 and hMSH2 that Confer Inherited Colorectal Cancer Susceptibility Using Denature Gradient Gel Electrophoresis (DGGE)

Chapter 12 s-RT-MELT: A Novel Technology for Mutation Screening

Chapter 13 Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes.

Chapter 14 Development of a scoring system to screen for BRCA1/2 mutations.

Chapter 15 Use of Splicing Reporter Minigene Assay to Evaluate the Effect on Splicing of Unclassified Genetic Variants

Chapter 16 Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay.

Chapter 17 Developing functional assays for BRCA1 unclassified variants.