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Mendeley readers
| Title |
Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers
|
|---|---|
| Published in |
Discover Nano, August 2015
|
| DOI | 10.1186/s11671-015-1044-7 |
| Pubmed ID | |
| Authors |
Yuan Yu, Lijun Kong, Lan Li, Naie Li, Peng Yan |
| Abstract |
The drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for cancer treatment. Firstly, the carbon nanotubes (CNTs) were selected as carriers to load the anticancer drug-doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous mats are a promising alternative for cancer treatment. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 2% |
| Unknown | 61 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 35% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 5 | 8% |
| Researcher | 4 | 6% |
| Other | 3 | 5% |
| Other | 3 | 5% |
| Unknown | 18 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Engineering | 8 | 13% |
| Agricultural and Biological Sciences | 5 | 8% |
| Materials Science | 4 | 6% |
| Medicine and Dentistry | 4 | 6% |
| Other | 12 | 19% |
| Unknown | 21 | 34% |