TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Siting Li, Feng Ge

Evolutionarily conserved and pleiotropic, the translationally controlled tumor protein (TCTP) is a housekeeping protein present in eukaryotic organisms. It plays an important role in regulating many fundamental processes, such as cell proliferation, cell death, immune responses, and apoptosis. As a result of the pioneer work by Adam Telerman and Robert Amson, the critical role of TCTP in tumor reversion was revealed. Moreover, TCTP has emerged as a regulator of cell fate determination and a promising therapeutic target for cancers. The multifaceted action of TCTP depends on its ability to interact with different proteins. Through this interaction network, TCTP regulates diverse physiological and pathological processes in a context-dependent manner. Complete mapping of the entire sets of TCTP protein interactions (interactome) is essential to understand its various cellular functions and to lay the foundation for the rational design of TCTP-based therapeutic approaches. So far, the global profiling of the interacting partners of TCTP has rarely been performed, but many interactions have been identified in small-scale studies in a specific biological system. This chapter, based on information from protein interaction databases and the literature, illustrates current knowledge of the TCTP interactome.