You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Chapter title |
Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing
|
|---|---|
| Chapter number | 2 |
| Book title |
Precision Medicine, CRISPR, and Genome Engineering
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-63904-8_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-963903-1, 978-3-31-963904-8
|
| Authors |
Benjamin E. Epstein, David V. Schaffer |
| Abstract |
With the recent advent of several generations of targeted DNA nucleases, most recently CRISPR/Cas9, genome editing has become broadly accessible across the biomedical community. Importantly, the capacity of these nucleases to modify specific genomic loci associated with human disease could render new classes of genetic disease, including autosomal dominant or even idiopathic disease, accessible to gene therapy. In parallel, the emergence of adeno-associated virus (AAV) as a clinically important vector raises the possibility of integrating these two technologies towards the development of gene editing therapies. Though clear challenges exist, numerous proof-of-concept studies in preclinical models offer exciting promise for the future of gene therapy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 33% |
| Netherlands | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 20% |
| Student > Bachelor | 10 | 19% |
| Student > Ph. D. Student | 7 | 13% |
| Researcher | 6 | 11% |
| Other | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 33% |
| Engineering | 6 | 11% |
| Agricultural and Biological Sciences | 4 | 7% |
| Immunology and Microbiology | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2018.
All research outputs
#3,698,523
of 23,007,887 outputs
Outputs from Advances in experimental medicine and biology
#608
of 4,961 outputs
Outputs of similar age
#73,869
of 421,256 outputs
Outputs of similar age from Advances in experimental medicine and biology
#52
of 490 outputs
Altmetric has tracked 23,007,887 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,961 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,256 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 490 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.