Chapter title |
The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex
|
---|---|
Chapter number | 1 |
Book title |
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
|
Published in |
Advances in experimental medicine and biology, November 2017
|
DOI | 10.1007/978-3-319-64371-7_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-964369-4, 978-3-31-964371-7
|
Authors |
Brites, Daniela, Gagneux, Sebastien, Daniela Brites, Sebastien Gagneux |
Abstract |
The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this chapter, we discuss the origins and the evolutionary forces shaping the genomic diversity of the human-adapted MTBC. Advances in whole-genome sequencing have brought invaluable insights into the macro-evolution of the MTBC, and the biogeographical distribution of the different MTBC lineages, the phylogenetic relationships between these lineages. Moreover, micro-evolutionary processes start to be better understood, including those influencing bacterial mutation rates and those governing the fate of new mutations emerging within patients during treatment. Current genomic and epidemiological evidence reflect the fact that, through ecological specialization, the MTBC affecting humans became an obligate and extremely well-adapted human pathogen. Identifying the adaptive traits of human-adapted MTBC and unraveling the bacterial loci that interact with human genomic variation might help identify new targets for developing better vaccines and designing more effective treatments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 133 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 20 | 15% |
Student > Ph. D. Student | 20 | 15% |
Student > Bachelor | 17 | 13% |
Researcher | 11 | 8% |
Student > Doctoral Student | 6 | 5% |
Other | 19 | 14% |
Unknown | 40 | 30% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 17% |
Immunology and Microbiology | 16 | 12% |
Agricultural and Biological Sciences | 15 | 11% |
Medicine and Dentistry | 13 | 10% |
Veterinary Science and Veterinary Medicine | 4 | 3% |
Other | 20 | 15% |
Unknown | 43 | 32% |