Chapter title |
Preclinical Effects of Antipsychotic Drugs
|
---|---|
Chapter number | 447 |
Book title |
Non-medical and illicit use of psychoactive drugs
|
Published in |
Current topics in behavioral neurosciences, January 2016
|
DOI | 10.1007/7854_2016_447 |
Pubmed ID | |
Book ISBNs |
978-3-31-960014-7, 978-3-31-960016-1
|
Authors |
Jenny Paola Berrío Sánchez, Bart A. Ellenbroek, Sánchez, Jenny Paola Berrío, Ellenbroek, Bart A. |
Abstract |
Antipsychotic drugs have been the drugs of choice for the treatment of schizophrenia ever since the introduction of chlorpromazine in the early 1950s of the last century. Since then, about 60 different antipsychotics have been introduced. Although pharmacologically these drugs show large differences, in terms of potency, duration of action and selectivity, all antipsychotics appear to reduce the positive symptoms of schizophrenia, while having little or no effect on the negative symptoms or the cognitive deficits. The only apparent exception is clozapine, which is also effective in therapy-resistant patients. On the other hand, antipsychotics induce significant side effects as well, including neurological, behavioural and metabolic side effects. In the present paper, we will discuss the preclinical pharmacology of the current antipsychotic drugs focussing both on the therapeutic and on side effects of these drugs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 25% |
Student > Master | 5 | 18% |
Student > Doctoral Student | 3 | 11% |
Student > Bachelor | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Other | 3 | 11% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 25% |
Agricultural and Biological Sciences | 4 | 14% |
Psychology | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Other | 4 | 14% |
Unknown | 7 | 25% |