Chapter title |
Interplay Between Microenvironmental Abnormalities and Infectious Agents in Tumorigenesis
|
---|---|
Chapter number | 16 |
Book title |
Infectious Agents Associated Cancers: Epidemiology and Molecular Biology
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-5765-6_16 |
Pubmed ID | |
Book ISBNs |
978-9-81-105764-9, 978-9-81-105765-6
|
Authors |
Qing Zhu, Feng Gu, Caixia Zhu, Yuyan Wang, Fang Wei, Qiliang Cai |
Abstract |
Emerging evidence has shown that the cell of microenvironmental abnormalities is a key factor that controls many cellular physiological processes including cellular communication, homing, proliferation, and survival. Given its central regulatory role, it is therefore not surprising that it is widely exploited by infectious agents for inducing pathogenesis. In the past decade, a number of oncogenic pathogens including viruses, bacteria, and parasites are demonstrated to take advantage of the tumor microenvironmental factors including hypoxia, oxidative stress, and cytokines, to create an extracellular environment more favorable for pathogen survival and propagation and escape from the host immune surveillance. Here we summarize and highlight the current understanding of the interplay between common tumor microenvironmental factors and oncogenic pathogens in promoting tumorigenesis. |
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Members of the public | 2 | 100% |
Mendeley readers
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Unknown | 6 | 100% |
Demographic breakdown
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Lecturer | 2 | 33% |
Student > Bachelor | 1 | 17% |
Student > Ph. D. Student | 1 | 17% |
Unknown | 2 | 33% |
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Neuroscience | 1 | 17% |
Medicine and Dentistry | 1 | 17% |
Unknown | 3 | 50% |