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Gene Correction

Overview of attention for book
Cover of 'Gene Correction'

Table of Contents

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    Book Overview
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    Chapter 1 RecTE Psy -Mediated Recombineering in Pseudomonas syringae
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    Chapter 2 Genome manipulations with bacterial recombineering and site-specific integration in Drosophila.
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    Chapter 3 Multiple Genetic Manipulations of DT40 Cell Line
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    Chapter 4 Gene Targeting of Human Pluripotent Stem Cells by Homologous Recombination
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    Chapter 5 Methods for the Assessment of ssODN-Mediated Gene Correction Frequencies in Muscle Cells.
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    Chapter 6 Small Fragment Homologous Replacement (SFHR): Sequence-Specific Modification of Genomic DNA in Eukaryotic Cells by Small DNA Fragments.
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    Chapter 7 Preparation and Application of Triple Helix Forming Oligonucleotides and Single Strand Oligonucleotide Donors for Gene Correction
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    Chapter 8 Triplex-Mediated Genome Targeting and Editing
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    Chapter 9 Targeting piggyBac Transposon Integrations in the Human Genome.
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    Chapter 10 Gene Targeting in Human-Induced Pluripotent Stem Cells with Adenoviral Vectors
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    Chapter 11 Enhanced Gene Targeting of Adult and Pluripotent Stem Cells Using Evolved Adeno-associated Virus
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    Chapter 12 Lentiviral Vectors Encoding Zinc-Finger Nucleases Specific for the Model Target Locus HPRT1
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    Chapter 13 Designing and Testing the Activities of TAL Effector Nucleases.
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    Chapter 14 A Bacterial One-Hybrid System to Isolate Homing Endonuclease Variants with Altered DNA Target Specificities
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    Chapter 15 Design and analysis of site-specific single-strand nicking endonucleases for gene correction.
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    Chapter 16 CRISPR-Cas-Mediated Targeted Genome Editing in Human Cells.
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    Chapter 17 RNA-Guided Genome Editing of Mammalian Cells
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    Chapter 18 Nuclease-Mediated Double-Strand Break (DSB) Enhancement of Small Fragment Homologous Recombination (SFHR) Gene Modification in Human-Induced Pluripotent Stem Cells (hiPSCs).
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    Chapter 19 AAV-Mediated Gene Editing via Double-Strand Break Repair
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    Chapter 20 Genetic Modification Stimulated by the Induction of a Site-Specific Break Distant from the Locus of Correction in Haploid and Diploid Yeast Saccharomyces cerevisiae
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    Chapter 21 A Southern Blot Protocol to Detect Chimeric Nuclease-Mediated Gene Repair
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    Chapter 22 High-Throughput Cellular Screening of Engineered Nuclease Activity Using the Single-Strand Annealing Assay and Luciferase Reporter
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    Chapter 23 An Unbiased Method for Detection of Genome-Wide Off-Target Effects in Cell Lines Treated with Zinc Finger Nucleases
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    Chapter 24 Identification of Off-Target Cleavage Sites of Zinc Finger Nucleases and TAL Effector Nucleases Using Predictive Models
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    Chapter 25 Method for Retinal Gene Repair in Neonatal Mouse
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    Chapter 26 In utero delivery of oligodeoxynucleotides for gene correction.
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    Chapter 27 Portal Vein Delivery of Viral Vectors for Gene Therapy for Hemophilia
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    Chapter 28 Gene Correction of Induced Pluripotent Stem Cells Derived from a Murine Model of X-Linked Chronic Granulomatous Disorder
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    Chapter 29 Efficient Transduction of Hematopoietic Stem Cells and Its Potential for Gene Correction of Hematopoietic Diseases
Attention for Chapter 9: Targeting piggyBac Transposon Integrations in the Human Genome.
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Chapter title
Targeting piggyBac Transposon Integrations in the Human Genome.
Chapter number 9
Book title
Gene Correction
Published in
Methods in molecular biology, February 2014
DOI 10.1007/978-1-62703-761-7_9
Pubmed ID
24557901
Book ISBNs
978-1-62703-760-0, 978-1-62703-761-7
Authors

Galvan DL, Kettlun CS, Wilson MH, Daniel L. Galvan, Claudia S. Kettlun, Matthew H. Wilson, Galvan, Daniel L., Kettlun, Claudia S., Wilson, Matthew H.

Abstract

DNA based transposon systems offer a technology for active and efficient delivery of genes into human cells. An emerging field is directed at manipulating such systems to achieve site-directed integration as compared to un-targeted integration which occurs with native or unmodified transposon systems. The naturally active piggyBac transposon system is derived from insects but has been shown to be very efficient in gene-modifying human cells. Recent efforts have utilized the fusion of DNA binding domains to the piggyBac transposase enzyme with the goal of targeting integration to specific locations in the human genome. In this chapter, we describe methodology for engineering and characterizing chimeric piggyBac transposase enzymes, including experimental approaches for evaluating activity and targeting specificity in the human genome.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 36%
Other 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Professor > Associate Professor 1 9%
Other 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 64%
Biochemistry, Genetics and Molecular Biology 2 18%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2014.
All research outputs
#20,238,443
of 22,765,347 outputs
Outputs from Methods in molecular biology
#9,865
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Outputs of similar age
#193,594
of 225,081 outputs
Outputs of similar age from Methods in molecular biology
#83
of 143 outputs
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So far Altmetric has tracked 13,090 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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