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Biosafety and Antibacterial Ability of Graphene and Graphene Oxide In Vitro and In Vivo

Overview of attention for article published in Discover Nano, October 2017
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Title
Biosafety and Antibacterial Ability of Graphene and Graphene Oxide In Vitro and In Vivo
Published in
Discover Nano, October 2017
DOI 10.1186/s11671-017-2317-0
Pubmed ID
Authors

Long Pang, Chunqiu Dai, Long Bi, Zhongshang Guo, Junjun Fan

Abstract

In recent years, graphene (G) and graphene oxide (GO) nanoparticles have begun to be applied in surgical implant surface modification. However, biosafety and antibacterial ability of G and GO are still unclear. In this study, the biosafety of G and GO in vitro was evaluated by co-culture with bone marrow mesenchymal stem cells (BMSCs) and biosafety in vivo was observed by implanting materials into mice muscle tissue. Biosafety results showed that 10 μg/ml was the safety critical concentration for G and GO. When the concentration was more than 10 μg/ml, the cytotoxicity of G and GO showed a dose-dependent manner.Antibacterial results showed that G presented the antibacterial ability with the concentration equal to and more than 100 μg/ml; GO presented the antibacterial ability with the concentration equal to and more than 50 μg/ml. The antibacterial effect of G and GO were in a dose-dependent manner in vitro.The GO or G concentration between 50 and 100 μg/ml may be the better range to keep the balance of cytotoxicity and antibacterial ability. Our study reveals that G and GO have potential to be used in clinic with good biosafety and antibacterial properties in a certain concentration range.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Student > Master 11 16%
Researcher 8 12%
Student > Bachelor 7 10%
Student > Doctoral Student 3 4%
Other 10 14%
Unknown 13 19%
Readers by discipline Count As %
Medicine and Dentistry 17 25%
Materials Science 11 16%
Agricultural and Biological Sciences 5 7%
Chemistry 3 4%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 13 19%
Unknown 17 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Discover Nano
#802
of 1,149 outputs
Outputs of similar age
#293,414
of 334,091 outputs
Outputs of similar age from Discover Nano
#12
of 16 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,149 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,091 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.