Chapter title |
Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
|
---|---|
Chapter number | 26 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_26 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Fiona Bartoli, Jessica Sabourin |
Abstract |
For a long time, Ca(2+) entry into cardiomyocytes was considered the sole domain of the L-type Ca(2+) channel. Recently, STIM1/Orai1-mediated store-operated Ca(2+) entry has been also reported to participate to Ca(2+) influx in cardiac cells and has emerged as a key player to alter Ca(2+) in the cardiomyocyte. In this review, we will highlight accumulated knowledge about the presence and the potential contribution of STIM1/Orai1-dependent SOCE to cardiac function and its role in the cardiac pathogenesis. Overall, even if STIM1/Orai1 proteins are present in the heart, contradictory results have been reported regarding their contribution to cardiac physiology and pathology, pointing out the necessity of further investigations, a major challenge over the coming years. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 16% |
Student > Master | 3 | 16% |
Student > Ph. D. Student | 2 | 11% |
Professor | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 11% |
Unknown | 7 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 26% |
Agricultural and Biological Sciences | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Immunology and Microbiology | 1 | 5% |
Unspecified | 1 | 5% |
Other | 0 | 0% |
Unknown | 8 | 42% |