| Chapter title |
Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods.
|
|---|---|
| Chapter number | 19 |
| Book title |
Galectins
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-1396-1_19 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-1395-4, 978-1-4939-1396-1
|
| Authors |
Mariana Salatino, Diego O Croci, Diego J Laderach, Daniel Compagno, Lucas Gentilini, Tomas Dalotto-Moreno, L Sebastián Dergan-Dylon, Santiago P Méndez-Huergo, Marta A Toscano, Juan P Cerliani, Gabriel A Rabinovich, Diego O. Croci, Diego J. Laderach, L. Sebastián Dergan-Dylon, Santiago P. Méndez-Huergo, Marta A. Toscano, Juan P. Cerliani, Gabriel A. Rabinovich |
| Abstract |
Formation of an aberrant and heterogeneous vascular network is a key pathological event in the multistep process of tumor growth and metastasis. Pro-angiogenic factors are synthesized and released from tumor, stromal, endothelial, and myeloid cells in response to hypoxic and immunosuppressive microenvironments which are commonly found during cancer progression. Emerging data indicate key roles for galectins, particularly galectin-1, -3, -8, and -9 in the regulation of angiogenesis in different pathophysiologic settings. Each galectin interacts with a preferred set of glycosylated receptors, triggers different signaling pathway, and promotes sprouting angiogenesis through different mechanisms. Understanding the role of galectins in tumor neovascularization will contribute to the design of novel anti-angiogenic therapies aimed at complementing current clinical approaches. Here we describe selected strategies and methods used to study the galectin-1 regulation by hypoxia and its role in blood vessel formation. |
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Demographic breakdown
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Mendeley readers
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|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 17% |
| Researcher | 2 | 17% |
| Student > Bachelor | 1 | 8% |
| Librarian | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 4 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Agricultural and Biological Sciences | 2 | 17% |
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| Social Sciences | 1 | 8% |
| Immunology and Microbiology | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 33% |