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Protein Design

Overview of attention for book
Cover of 'Protein Design'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 De Novo Design of Stable α-Helices
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    Chapter 2 Design of Monomeric Water-Soluble β-Hairpin and β-Sheet Peptides
  4. Altmetric Badge
    Chapter 3 Combination of theoretical and experimental approaches for the design and study of fibril-forming peptides.
  5. Altmetric Badge
    Chapter 4 Posttranslational Incorporation of Noncanonical Amino Acids in the RNase S System by Semisynthetic Protein Assembly
  6. Altmetric Badge
    Chapter 5 Design, Synthesis, and Study of Fluorinated Proteins
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    Chapter 6 High-quality combinatorial protein libraries using the binary patterning approach.
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    Chapter 7 Methods for Library-Scale Computational Protein Design
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    Chapter 8 Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction
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    Chapter 9 Identification of Protein Scaffolds for Enzyme Design Using Scaffold Selection
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    Chapter 10 Computational Design of Novel Enzymes Without Cofactors
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    Chapter 11 De Novo Design of Peptide Scaffolds as Novel Preorganized Ligands for Metal-Ion Coordination
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    Chapter 12 Computational Design of Metalloproteins
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    Chapter 13 Incorporation of Modified and Artificial Cofactors into Naturally Occurring Protein Scaffolds
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    Chapter 14 Computational Redesign of Metalloenzymes for Catalyzing New Reactions.
Attention for Chapter 6: High-quality combinatorial protein libraries using the binary patterning approach.
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  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Chapter title
High-quality combinatorial protein libraries using the binary patterning approach.
Chapter number 6
Book title
Protein Design
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-4939-1486-9_6
Pubmed ID
25213413
Book ISBNs
978-1-4939-1485-2, 978-1-4939-1486-9
Authors

Luke H Bradley, Luke H. Bradley

Abstract

Protein combinatorial libraries have become a platform technology for exploring protein sequence space for novel molecules for use in research, synthetic biology, biotechnology, and medicine. To expedite the isolation of proteins with novel/desired functions using screens and selections, high-quality approaches that generate protein libraries rich in folded and soluble structures are desirable for this goal. The binary patterning approach is a protein library design method that incorporates elements of both rational design and combinatorial diversity to specify the arrangement of polar and nonpolar amino acid residues in the context of a desired, folded tertiary structure template. An overview of the considerations necessary to design and construct binary patterned libraries of de novo and natural proteins is presented.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Other 1 17%
Student > Doctoral Student 1 17%
Student > Master 1 17%
Unknown 1 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 67%
Immunology and Microbiology 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2015.
All research outputs
#14,785,250
of 22,763,032 outputs
Outputs from Methods in molecular biology
#4,675
of 13,088 outputs
Outputs of similar age
#183,113
of 305,294 outputs
Outputs of similar age from Methods in molecular biology
#182
of 597 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,088 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,294 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 597 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.

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