Drug Discovery in Africa

Chapter 1 Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases

Chapter 2 The National Cancer Institute and Natural Product-Based Drug Discovery in Africa

Chapter 3 Tuberculosis Drug Discovery: Target Identification and Validation

Chapter 4 Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response

Chapter 5 Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug Discovery Paradigms

Chapter 6 Searching for Drugs That Target Multiple Receptors for Anthelmintics from African Natural Products

Chapter 7 Application of In Silico, In Vitro and In Vivo ADMET/PK Platforms in Drug Discovery

Chapter 8 Marine Bioprospecting in Southern Africa

Chapter 9 Natural Product-Based Drug Discovery Against Neglected Diseases with Special Reference to African Natural Resources

Chapter 10 “Now I Heal with Pride”—The Application of Screens-to-Nature Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery

Chapter 11 Innovative Approaches to Exploiting Traditional Medicines in Malaria

Chapter 12 Anticancer Drug Repositioning Against Tropical Diseases: The Example of Methotrexate in the Treatment of Malaria

Chapter 13 Tackling the Problem of Antimalarial Resistance

Chapter 14 Random and Rational Approaches to HIV Drug Discovery in Africa

Chapter 15 Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors

Chapter 16 Natural Products and Antimalarial Drugs: Will Africa Provide the Next Major Breakthrough?

Chapter 17 Nanomedicine in the Development of Drugs for Poverty-Related Diseases